Sanofi

Elf Sanofi

Societe Anonyme Sanofi

Seperic

Synthelabo

Delalande S.a.

Choay, S.a.

Vetoquinol S.a.

Camille G Wermuth

Paul Worms

Jean-Jacques Bourguignon

Kathleen Biziere

Roger Brodin

Robert Boigegrain

Pierre M Roger

Dominique Olliero

Jean P Kan

Horace Davi

Danielle Gully

Jean-Paul Kan

Michel Jacques Geslin

Gilles V Courtemanche

Jean Choay

Bruno Giethlen

Gerard Valette

Gilles Courtemanche

Christophe Morice

Paola Ciapetti

Claudie Suzanne Gautier

Jean-Pierre Chambon

Daniele Anne Gully

Françoise Leblanc

Florence Chery-Mozziconacci

Marc Schneider

Jean Schwartz

Sandrine Ropp

Michel Heaulme

Gilbert Schlewer

Claudie Gautier

Daniel A Gully

Jean-Luc Dimicoli

Joseph G Bieth

Substituted 4-phenylaminothiazoles, their process of preparation and the

The invention concerns compounds of the formula I: ##STR1## in which R.sub.1 to R.sub.5 are as defined in claim 1. These compounds find their application in the treatment of pathologies involving CRF.

Branched-amino-substituted thiazoles, processes for their preparation

The present invention relates to pyridazine derivatives of formula: ##STR1## which are useful as ligands of cholinergic receptors, in particular, receptors of the M.sub.1 type.

Pyridazine derivatives

The invention relates to the derivatives of formula I: ##STR1## in which R.sub.1 represents a phenyl or naphthyl radical (optionally substituted), R.sub.2 represents a hydrogen or halogen atom or an alkyl, hydroxymethyl or formyl radical, R.sub.3 represents an alkyl, cycloalkyl, alkenyl, cycloalkylalkyl or phenyl radical, R.sub.4 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl radical, R.sub.5 represents an alkyl, cycloalkyl, cycloalkylalkyl or alkenyl radical or a radical of formula B: ##STR2## (p=0, 1, 2 or 3), R.sub.6 represents a phenyl, pyridyl, imidazolyl, pyrrolyl, thienyl or furyl radical, optionally substituted, or a cycloalkyl radical,

Branched alkylamino derivatives of thiazole, processes for preparing

The invention relates to 3-aminopyridazine derivatives. These compounds have the formula ##STR1## in which: R.sub.V is a linear or branched C.sub.1 -C.sub.4 alkyl group;

3-(N-azabicycloalkyl)aminopyridazine derivatives and pharmaceutical

The invention relates to the use of 5-alkylpyridazine derivatives of the formula ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.2 and R.sub.3 independently are a C.sub.1 -C.sub.4 alkyl group, or R.sub.2 and R.sub.3, taken with the nitrogen atom to which they are bonded, form a morpholino group, or one of their pharmaceutically acceptable salts, for the preparation of pharmaceutical compositions for combating pathological conditions associated with a cortical cholinergic deficiency, especially for the treatment of degenerative syndromes associated with senescence.

Use of 5-alkylpyridazine derivatives as drugs active on the cholinergic

The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors. These derivatives have the formula ##STR1## in which X=O, S, --OCH.sub.2 -- or --SCH.sub.2 --; R.sub.1 =H or halogen; and R.sub.2 = ##STR2## in which Alk is an alkylene group and R.sub.3, an R.sub.4, which are identical or different, are hydrogen or a lower alkyl group, or R.sub.3 and R.sub.4, with the nitrogen atom to which they are bonded, form a 5- or 6-membered cyclic amino group optionally containing a second heteroatom; or R.sub.2 is a group ##STR3## where R.sub.5 =C.sub.1 -C.sub.4 -alkyl. Application: agonists of cholinergic receptors.

Tricyclic cholinergic receptor agonists

The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors and to drugs containing them. These derivatives have the following formula: ##STR1## in which: X represents a group (CH.sub.2).sub.n, n representing an integer equal to 2, 3 or 4, or alternatively a vinylene group or a methylvinylene group;

Novel tricyclic derivatives which are agonists of cholinergic receptors,

The present invention relates to imidazo[1,2-b]-pyridazines having the formula: ##STR1## in which: R.sub.1 represents hydrogen, a halogen atom, a C.sub.1 -C.sub.4 alkoxy group or a C.sub.1 -C.sub.4 alkyl group occupying one of the free positions of the benzene ring; R.sub.2 represents hydrogen, a C.sub.1 -C.sub.4 alkyl group or a phenyl group; R.sub.3 denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or a phenyl group; and R.sub.4 R.sub.5 represent hydrogen or a C.sub.1 -C.sub.4 alkyl group, or R.sub.4 and R.sub.5 form, together with the nitrogen atom to which they are bonded, a 5-membered or 6-membered heterocycle optionally containing a second heteroatom. Application: drugs, especially for the treatment of cortical cholinergic deficiencies.

Imidazo[1,2-]pyridazines for cortical cholinergic deficiencies

The invention relates to derivatives of 2,3-dihydro 3-imino-pyridazine responding to general formula: ##STR1## in which: A represents an atom of oxygen or of sulfur;

Derivatives of 3-imino-pyridazine, process for obtaining them and

The present invention relates to derivatives of pyridazine of formula: ##STR1## in which R.sub.1 is alkyl or a phenyl group and R.sub.2 is H or R.sub.1 and R.sub.2 form, with the carbon atoms to which they are attached, a benzene cycle, R.sub.3 is H or phenyl and R.sub.4 is ##STR2## in which R.sub.5 is H or CH.sub.3 and R.sub.6 is H, OH, OR or OCOR; it also relates to a process for preparing the products of formula (I) and to the drugs containing at least one of said products.

New derivatives of pyridazine active on the central nervous system

The present invention relates to derivatives of 4-methyl 6-phenyl pyridazine of formula: ##STR1## in which R is OH or H, R.sub.1 is H or ##STR2## n being 0 or 1, X being H, Y being H or alkyl or X and Y forms an ethylene or oxoethylene group;

Derivatives of 4-methyl 6-phenyl pyridazine, active on the central

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Strasbourg, France

Camille G Wermuth