Vertex Pharmaceuticals, Inc.

Camil Elie Sayegh

Luc J Farmer

Claudio F Sturino

Yeeman K Ramtohul

Constantin G Yannopoulos

Bingcan Liu

Monica Bubenik

Frederic Vallee

Julien Martel

Jean-Eric Lacoste

Janek Szychowski

Stephanie Lessard

Miguel St-Onge

Pierre-Andre Fournier

The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.

Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway

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Dorval, Canada

Camil Elie Sayegh