Pellepharm, Inc.

Nflection Therapeutics, Inc.

Sol-Gel Technologies Ltd.

Cameron Robert Stevenson

Marc Barry Brown

Charles Rodney Greenaway Evans

Brendan Philip Brady

Christopher Powala

Elaine Morefield

Charles Rodney Evans

Provided herein are topical formulations including a compound of formula (I) and methods of using these topical formulations for the treatment of skin diseases, wherein the topical formulations include non-aqueous gel, aqueous gel, and emulsion-based formulations; and the compound of formula (I) is represented by wherein R, R, R, R, R, and Rare as defined and described herein.

Formulations of pyrrolopyridine-aniline compounds

Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

Growing community of inventors

Guildford, United Kingdom

Cameron Robert Stevenson