Wisconsin Alumni Research Foundation

Harvard College

Universidad De Costa Rica

Cameron Robert Currie

Brian Fox

Taichi Takasuka

Adam Joel Book

Jon Clardy

David Andes

Timothy Bugni

Emily Beebe

Robert Joseph Stankey

Ethan Van Arnam

Monica Tallarico Pupo

Clarissa Sit

Humberto Enrique Ortega Dominguez

Antonio Ruzzini

Adrian Alberto Pinto-Tomas

Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insectand having a chemical formula of CHOis also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such asand, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.

Cyphomycin, compositions and uses thereof

Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claims.

Antifungal compounds

A heterologous gene cassette useful for creatingspecies with enhanced capability of growing on a cellulosic polysaccharide substrate, wherein the cassette comprises at least two members of the following categories: a) a GH6 gene, b) an AA10 gene, c) a GH48 gene, d) a GH5 gene and e) either (i) a GH9 gene, (ii) a GH9 gene and a GH12 gene, or (iii) a GH12 gene is disclosed.

Method of creating industrial streptomyces with capability to grow on cellulosic polysaccharide substrates

A method of digesting a lignocellulosic material is disclosed. In one embodiment, the method comprises the step of exposing the material to an effective amount ofsp. ActE secretome such that at least partial lignocellulosic digestion occurs.

Method and compositions for improved lignocellulosic material hydrolysis

Growing community of inventors

Madison, WI, United States of America

Cameron Robert Currie