University of Pennsylvania

University of Rochester

Cameron J Koch

William R Dolbier, Jr

An-Rong Li

Edith M Lord

Alexander V Kachur

Sydney M Evans

Ann R Kennedy

Brian R James

Kirsten A Skov

Chyng-Yann Shiue

Ian R Baird

Xingsheng Wan

NovelF-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Preparation of compounds useful for the detection of hypoxia

NovelF-flourine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia, and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Detection of hypoxia

The invention relates to the discovery that the concentration of free cysteine in mammalian tumor tissue is elevated compared with the concentration of free cysteine in non-tumor tissue of the same origin. Elevated levels of free cysteine is, in turn, correlated with resistance of tumors to antitumor therapy such as chemotherapy and radiation therapy. Therefore, the invention further relates to methods of detecting the presence of tumors in mammalian tissues, assessing the resistance of tumors to antitumor therapies as it relates to free cysteine concentration, and to the identification of compounds which affect free cysteine concentration in mammalian tissues.

Methods for diagnosis and treatment of tumors in humans

Nitroaromatic compounds for the detection of hypoxia

Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Monoclonal antibodies and a method capable of detecting Bowman Birk inhibitor metabolites in a sample of body fluid or tissue are provided.

Method of monitoring exposure to Bowman Birk inhibitor using monoclonal

Monoclonal antibodies and a method capable of detecting BBI metabolites in a sample of body fluid or tissue are provided.

Growing community of inventors

Aldan, PA, United States of America

Cameron J Koch