Novartis Ag

Cameron Chuck-munn Lee

Tanzina Fazal

Chandra Vargeese

Rohan Eric John Beckwith

Thomas Zabawa

Gabriel Grant Gamber

Jeremy Lee Baryza

Ritesh Bhanudasji Tichkule

Junping Zhao

Shuangxi Wang

Laura Ellen West

Crystal Byers

Cornelia Jutta Forster

Christopher Michael Adams

Edward Charles Hall

Myriam April

Jean-Baptiste Georges Armand Langlois

Nicole Gerwin

Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

Sustained release delivery systems comprising traceless linkers

Sustained delivery of angiopoetin-like 3 polypeptides

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Lipids and lipid compositions for the delivery of active agents

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

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Cambridge, MA, United States of America

Cameron Chuck-munn Lee