Leland Stanford Junior University

Calvin Jay Kuo

James Neal

Akifumi Ootani

Irving L Weissman

David B Camarillo

Mark Lee

Tannishtha Reya

Lyndia Chun Wu

Kaveh Laksari

Frank Kuhnert

Functional in vitro assays are provided for determining patient specific responsiveness to immunotherapy agents within a clinically actionable time frame.

Methods to preserve tumor-stromal interactions in culture and therapeutic predictive applications thereof

An oral appliance includes: 1) a body defining a channel to accommodate an upper dentition; and 2) a motion sensor. The body includes a front portion defining a recess, and the motion sensor is affixed to the front portion.

Oral appliance for measuring head motions by isolating sensors from jaw perturbance

Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.

Ex vivo culture, proliferation and expansion of intestinal epithelium

The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to an individual an agent that modulates the expression or activity of Egfl7, where an agonist of Egfl7, including an Egfl7 polypeptide, decreases angiogenesis. In one embodiment, the methods of the invention relate to inhibiting pathological angiogenesis by enhancing activity of Egfl7, which method may be carried out in conjunction with administration of one or more other anti-angiogenic agents.

Methods of modulating angiogenesis

Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.

Growing community of inventors

Palo Alto, CA, United States of America

Calvin Jay Kuo