Eli Lilly and Company

Calvin E Higgens

Karl H Michel

Ramakrishnan Nagarajan

Marvin Gorman

Marvin M Hoehn

Robert L Hamill

Richard M Gale

A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.

A-40104 Antibiotics and process for production thereof

Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.

Antibiotic A16886 and process for production thereof

7-(5-Amino-5-carboxyvaler-amido)-3-(carbamoyloxymethyl)-7-methoxy-3-cep

Antibiotic A16886II

A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.

A-40104 antibiotics and process for production thereof

7-(5-Am

Antibiotic A-35512 complex, comprising microbiologically active, related factors A, B, C, E and H, is produced by submerged aerobic fermentation of Streptomyces candidus NRRL 8156. The individual A-35512 factors are separated and isolated by chromatography. The A-35512 antibiotics are antibacterial and growth-promoting agents and increase feed-utilization efficiency in animals. In addition, A-35512 factor B is useful in the treatment of dental caries and acne.

Antibiotic A-35512 and process for production thereof

Antibiotic A-35512 for increasing feed utilization efficiency in an

Antibiotic A16884 and its salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces lipmanii NRRL 3584.

7-(5-Amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid

Antibiotic A-22082 is produced by submerged aerobic fermentation of Aspergillus nidulans NRRL 8112. Antibiotic A-22082 is an antifungal agent.

Antibiotic A-22082 and process for production thereof

Antibiotic A16884

Antibiotic A23187 and process for production thereof by submerged aerobic culture of Streptomyces chartreusis NRRL 3882. The antibiotic demonstrates antimicrobial activity and exhibits ionophorous properties, with a specificity for divalent cations.

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Indianapolis, IN, United States of America

Calvin E Higgens