Other

The University of British Columbia

Centre for Drug Research and Development

Calvin D Roskelley

Kelly Marshall McNagny

John Stephen Babcook

Bradley John Hedberg

Michael R Hughes

Christopher John Bond

Jan Peter Bergqvist

Helen Merkens

Klas Ola Blixt

Ismael Samudio

Katherine Grace MacDonald

Anna Von Rossum

Pamela Megan Dean

Aruna Somasiri

Diana Canals Hernaez

David Huntsman

Kelley Marshall Mcnagny

Kimberly Ashely Snyder

Kelly M Mcnagny

The present invention is directed to anti-podocalyxin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of cancer.

Anti-podocalyxin antibodies and methods of using the same

The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated Ab1 and 3G2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said anti bodies for targeting tumour endothelial cells that express podocalyxin.

Methods and kits for detecting cancer and monitoring cancer progression are described. The method involves analyzing a sample containing nucleic acids or proteins from a patient for decreased expression of endoglycan and/or increased expression of podocalyxin.

Methods for detecting and treating cancer

Growing community of inventors

Vancouver, Canada

Calvin D Roskelley