Tidal Photonics, Inc.

Digital Optical Imaging Corporation

Xillix Technologies Corporation

Motic China Group Co., Ltd.

Other

Provincial Health Services Authority

Accumed International, Inc.

Monogen, Inc.

Biomax Technologies Inc.

Oncometrics Imaging Corp.

Derma Technologies, Inc.

Perceptronix Medical, Inc. and British Columbia Cancer Agency

Motic China Group, Ltd.

Calum E MacAulay

Branko Mihael Palcic

Haishan Zeng

Nicholas MacKinnon

Ulrich Stange

Bruno W Jaggi

David M Garner

Pierre Lane

Stephen C-t Lam

Andrew L P Dlugan

S Alan Harrison

Nicholas B MacKinnon

David I McLean

Gary William Ferguson

Richard W Cline

Harvey Lui

Mario Zganec

Peter D Whitehead

Christopher R Thompson

Margareta Flezar

Peter William Payne

Jaka Lavrencak

Amedeus E Profio

Alexei K Doudkine

Bruce M McManus

Alexei Doudkine

Jaclyn Y-c Hung

Nico Bodenschatz

A system provides combined diffuse optical microscopy (DOM) and fluorescence endomicroscopy (FE). The system may use a single light source which generates structured illumination for both modalities. FE and DOM images may be displayed for qualitative assessment. Quantitative assessments may be based on both FE and DOM images. The quantitative assessments may be applied to characterize tissues. Some embodiments provide multi-spectral DOM.

Dual mode biophotonic imaging systems and their applications for detection of epithelial dysplasia in vivo

Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.

Methods and apparatus for imaging using a light guide bundle and a spatial light modulator

Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.

Apparatus and methods relating to wavelength conditioning of illumination

Apparatus and methods relating to microscopes having specific control of the light that contacts a sample and/or a light detector, such as the eye of the user, a charge couple device or a video camera. The improved control includes enhanced, selective control of the angle of illumination, quantity of light and location of light reaching the sample and/or detector. The microscopes comprise one or more spatial light modulators in the illumination and/or detection light path of the microscope at one or both of the conjugate image plane of the aperture diaphragm of the objective lens and the conjugate image plane of the sample.

Apparatus and methods relating to spatially light modulated microscopy

Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of malignancy-associated changes (MAC) in cells, which can be used for the detection of cancer. The programs and methods detect cancer in one tissue by detecting MAC in another tissue, such as associated tissues or non-associated tissues. Examples of associated tissues include nipple aspirates or ductal washings to detect breast cancer, and sputum or bronchial lavage to detect lung cancer. Examples of non-associated tissues include buccal mucosa to detect lung or breast cancer.

Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer

Methods and apparatus for imaging using a light guide bundle and spatial light modulator

Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can also improve the signal-to-noise ratio and other aspects of the measurements.

Light modulated microarray reader and methods relating thereto

Apparatus for acquiring in vivo images of a site of interest within the internal organs of a body. The apparatus includes an elongate, flexible catheter. The catheter is introducible into the body and has a first end that remains external to the body and a second and positionable adjacent the site of interest. A movable scanning unit having at least one sensor for acquiring images is housed adjacent the second end of the catheter. There is a drive mechanism to control movement of the movable scanning unit from the first external end of the catheter to acquire multiple images of the site of interest. The drive mechanism has a control element extending the length of the catheter lumen adapted for linear movement within the lumen to generate linear or rotational movement of the scanning unit.

Apparatus for in vivo imaging of the respiratory tract and other internal organs

A method for detecting malignancy-associated changes. A sample of cells is obtained and stained to identify the nuclear DNA material. The sample is imaged with a digital microscope. Objects of interest are identified in the sample of cells based on the intensity of the pixels that comprise the object versus the average intensity of all pixels in the slide image. An exact edge is located for each object and variations in the illumination intensity of the microscope are compensated for. A computer system calculates feature values for each object and, based on the value of the features, a determination is made whether the cell exhibits malignancy-associated changes or not.

Method and apparatus for automatically detecting malignancy-associated changes

Apparatus and methods that improve the depth resolution of confocal microscopy images using out-of-focus information from within the focal plane of interest (from the x-y direction) and/or from planes above and below the focal plane of interest (from the z-direction). The interaction of (a) a reflective surface or other light-emanating material and (b) the PSF formed by a confocal microscope results in &ldquo;out-of-focus&rdquo; information in, above and below the focal plane; this &ldquo;out-of-focus&rdquo; information can be measured. Comparing the measurements in the x-y plane, preferably at a plurality of z-positions, can improve the resolution along each of the x, y, and z-axes, increase the number of the photons used in the system, thus improving the signal to noise ratio, and help correct for aberrations, such as spherical aberrations or other optical aberrations, in the optical system of a microscope.

Methods and apparatus for improved depth resolution use of out-of-focus information in microscopy

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Vancouver, Canada

Calum E MacAulay