Icahn School of Medicine at Mount Sinai

Mount Sinai School of Medicine

Calogera M Simonaro

Edward Howard Schuchman

Helen Vlassara

Gary E Striker

The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.

Ceramidase and cell differentiation

The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-&#x3b1; therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-&#x3b1; therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-&#x3b1; therapy.

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Haworth, NJ, United States of America

Calogera M Simonaro