Wyeth

Callain Younghee Kim

Puwen Zhang

Casey Cameron McComas

Wayne Everett Childers

Eugene Anthony Terefenko

Eugene John Trybulski

Paige Erin Mahaney

Stephen Todd Cohn

Gavin David Heffernan

Joseph Peter Sabatucci

An Thien Vu

Michael Anthony Marella

Richard Dale Coghlan

Fei Ye

Edward J Podlesny

Jerome C Wu

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Phenylaminopropanol derivatives and methods of their use

Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharmaceutical compositions containing the same and therapeutic uses. The bicyclic amide derivatives are useful for treating a variety of conditions associated with the abnormal modulation of one or more Kv1.1 voltage-gated potassium channels.

Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof

Growing community of inventors

Collegeville, PA, United States of America

Callain Younghee Kim