Boston University

Caleb J Bashor

James Joseph Collins

Ahmad S Khalil

Nikit Patel

Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.

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Boston, MA, United States of America

Caleb J Bashor