Merck Sharp + Dohme Corp.

Walter and Eliza Hall Institute of Medical Research

Msd R&d (China) Co., Ltd.

Msd R&d Co., Ltd.

Cailing Zhang

Bin Hu

John A McCauley

David Brian Olsen

Zhuyan Guo

Manuel De Lera Ruiz

Michael J Kelly, Iii

Zhiyu Lei

Alan F Cowman

Dongmei Zhan

Lianyun Zhao

Brad Sleebs

Paola Favuzza

Jennifer K Thompson

Tony Triglia

Michael J Kelly Iii

John A Mccauley

Methods of treating malaria comprising administration of compounds of Formula (I') or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

Antimalarial agents

Growing community of inventors

Shanghai, China

Cailing Zhang