Chinese Academy of Sciences

Sichuan University

Caihong Zhou

Mingwei Wang

Fajun Nan

Na Li

Jie Gao

Xin Xie

Yong Deng

Qing Liu

Wenlong Wang

Guangxing Wang

Xin Hui

Haoran Su

Dacheng Yang

Xinchuan Dai

Provided are a dsRNA construct of an orphan G-protein-coupled receptor GPR160 gene related to prostate cancer and the use thereof, wherein the dsRNA construct of the GPR160 gene and a composition thereof can prevent or treat prostate cancer.

Prevention, diagnosis and treatment of cancer overexpressing GPR160

The present invention provides a substituted cyclic compound of the following general formula I or II: its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.

Substituted cyclic compound, its preparation process and its medical use

The present invention provides the glucagon-like peptide-1 receptor agonists. It is indicated that the agonists have good binding capability to glucagon-like peptide-1 receptor by pharmacological tests. The present invention also provides the preparation of the agonists.

Glucagon-like peptide-1 receptor agonists, the preparation and the use of the same

Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities. 

Non-steroidal androgen receptor modulators, preparation process, pharmaceutical composition and use thereof

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Shanghai, China

Caihong Zhou