University of Michigan

Onl Therapeutics. Inc.

Cagri Giray Besirli

Gun-Ho Kim

Stephen Lee Smith

Kevin P Pipe

David Noam Zacks

Alexander James Bridges

Francis X Smith

Linda Lea Johnson

John K Freshley

William A Hunke

Ethan Sylvain

Gregor Seidman

Thomas Wubben

Karin Ytterbo

Stephen Smith

Kevin Wiese

Joseph Hendrickson

Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.

Peptide compositions and methods of use

Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.

Compositions and methods for treating eye disorders

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

Applicator for cryoanesthesia and analgesia

The present invention provides compositions and methods to prevent apoptosis. In particular, provided herein are compositions and methods which prevent FAS-mediated photoreceptor apoptosis.

Methods of inhibiting photoreceptor apoptosis by eliciting the Faim2 antiapoptotic pathway

Growing community of inventors

Ann Arbor, MI, United States of America

Cagri Giray Besirli