University of Washington

Georgia Tech Research Corporation

Emory University

Queen's University at Kingston

Fred Hutchinson Cancer Center

Kingston Health Sciences Centre

Caelan Radford

Christopher B Doering

Eric Gaucher

Harold Trent Spencer

Philip M Zakas

Jesse Bloom

Adam S Dingens

Katharine H D Crawford

David Lillicrap

Cell-stored barcoded viral protein deep mutational scanning libraries are described. The libraries can be used to map resistance mutations to therapeutic treatments. The libraries can be used to predict viruses that become resistant to therapeutic compounds and/or may more easily evolve to infect new species. The libraries can also be used to more safely study dangerous viruses that normally require high safety biocontainment facilities. The libraries include features that allow efficient collection and assessment of informative data, obviating many bottlenecks of previous approaches.

Cell-stored barcoded deep mutational scanning libraries and uses of the same

A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

Von Willebrand factor proteins for treating bleeding disorders

Growing community of inventors

Seattle, WA, United States of America

Caelan Radford