University of Pennsylvania

Smiths Detection Inc.

Other

C William Hanson, Iii

Erica R Thaler

Timothy E Burch

Eric A Hoffman

Bryan E Marshall

Carol Marshall

Charles F Ward, Iii

Carl Medsker

Fred Frasch

Methods and devices for rapid diagnosis and monitoring a patient for disease or effectiveness of treatment in real time. In preferred embodiments, the methods and devices comprise contacting an array of sensors with a sample from a mammal suspected of having a disease to generate a sensor array profile, measuring a clinical diagnostic marker for the suspected disease, and then developing a diagnosis using the sensor array profile in combination with the clinical diagnostic marker.

Detection, diagnosis, and monitoring of a medical condition or disease with artificial olfactometry

A pelvic extension frame for removable attachment to the waist. The pelvic extension frame comprises a yoke having a first end, a second end, a medial aspect and a longitudinal axis. A harness is connected to the medial aspect of the yoke. A first coupling is connected to the first end of the yoke. The first coupling has a first pivot and a first mount. The first pivot is pivotable about the longitudinal axis. A second coupling is connected to the second end of the yoke. The second coupling has a second pivot and a second mount. The second pivot is pivotable about the longitudinal axis.

Pelvic extension frame

The presence of a pathologic process in a lung of a mammal is detected by applying exhaled gas of a mammal to an electronic nose. Data derived from the electronic nose is used to determine whether a pathologic process is present in the lung of the mammal. The pathologic process may be a lung infection such as pneumonia.

Method and system of diagnosing intrapulmonary infection using an electronic nose

The presence of a pathologic process in a lung of a mammal is detected by applying exhaled gas of a mammal to an electronic nose ( ). Data derived from the electronic nose ( ) is used to determine whether a pathologic process is present in the lung of the mammal. The pathologic process may also be a lung infection such as pneumonia. Also, a mammalian fluid sample obtained from the sinus or nose is applied to an electronic nose ( ) to determine if the fluid sample contains significant amounts of cebrospinal fluid.

Diagnosing intrapulmonary infection and analyzing nasal sample

This invention describes a patient monitoring system which creates graphical displays of various pulmonary and other patient functions so that physicians and clinicians can quickly and accurately make decisions about the patient's care based on the graphical displays while in the intensive care unit. Patient functions are monitored and pulmonary models are implemented to graphically reveal relationships between the basic information input to the system from monitoring devices and the models so that physicians can utilize the revealed relationships to make informed accurate diagnoses and design therapeutic plans concerning the patient.

Intensive care information graphical display

A method and apparatus for unifying the pressure/flow and ventilation perfusion ratios is disclosed. The method comprises the following steps: determining the initial health condition of a patient so as to define a pulmonary pressure flow curve for each of a plurality of lung compartments of said patient; applying a stimulus of hypoxic pulmonary vasoconstriction to the pressure flow curve for each compartment to obtain a pressure flow curve for each of said plurality of compartments; and deriving a pulmonary artery pressure value corresponding to a ventilation/perfusion ratio that satisfies both the individual and total pressure flow requirements for said pulmonary pressure/flow curves.

Method and apparatus for unifying the ventilation/perfusion and

Method and apparatus for maximizing the volume of blood pumped by a heart and maximizing ventilation/perfusion matching in the lungs, wherein the lungs are ventilated by a respirator in response to a control signal, are shown to include a series of monitors for generating a heart signal such as an electrocardiogram, a lung air flow rate signal and a lung air pressure signal and a controller, connected to receive these signals and to the respirator. The controller monitors the signals and generates the control signal when the heart signal is representative of a desired in point in the pumping cycle of the heart and the other signals indicate desired flow rate and pressure in the lungs. In a preferred embodiment, the control signal is generated so as to maximize the augmentation of the pumping of the heart and to minimize the trapping of air in the lungs. Using the present invention, blood being pumped from the heart is assisted by the ventilation of the lungs. It is preferred for the controller to include a series of threshold detectors for detecting when the signals exceed threshold levels. It is especially preferred for the detector to detect a point during ventricular contraction. It is especially preferred for the apparatus to further include a delay mechanism, interposed between the respirator and the controller, for delaying the control signal.

Method and apparatus for ECG gated ventilation

A ventiltor for ventilating the lungs of a patient is described as including a valve member connected to a fluid source and to the patient. The valve member controls the flow of fluid to the patient in response to a control signal. A programmable controller, connected to the valve member, generates the control signal for the valve member. The programmable controller includes a memory in which fluid flow rate information has been stored and a microprocessor. The controller is operative to determine a desired fluid flow rate in relation to the flow rate information and for generating the control signal in relation to the flow rate signal. In a preferred embodiment the valve member includes a plurality of first and second valves, wherein each of the second valves are operative to allow fluid to pass therethrough at flow rates which are multiples of a master flow rate. It is especially preferred for the multiple for each second valve to be equal to the value 2.sup.M, where M is an integer from zero to one less than the number of second valves. If the memory further has stored therein pressure information it is desireable to include a first monitor for generating a heart signal, a second monitor for generating a lung flow rate and a third monitor for generating a lung pressure signal. In such a situation it is preferred for the controller to be connected to receive the heart signal, the flow rate signal and the pressure signal, and for the control signal to be generated in response to such signals.

Growing community of inventors

Radnor, PA, United States of America

C William Hanson, Iii