University of Utah Research Foundation

Idaho Technology, Inc.

C Wade Dummer

Carl Thomas Wittwer

Virginie E Dujols

Methods of identifying the type of a cell are provided, the methods comprising determining the Tprofile of a sample rRNA or fragment thereof from the cell using a double stranded nucleic acid-specific dye, wherein a match between the determined Tprofile and the Tprofile of a corresponding rRNA or fragment thereof of a cell from a known cell type indicates that the sample rRNA is from the known cell type.

Species identification by melting analysis of secondary structure of single stranded nucleic acids

A novel method for characterizing nucleic acids. A nucleic acid is combined with a double stranded nucleic acid-specific dye to form a detectable complex between the dye and one or more double stranded structures within the nucleic acid. The combination is then exposed to varying temperatures and the fluorescence emission of the dye is measured to determine the melting temperature(s) for the double stranded structures. In some embodiments that melting temperature profile is then compared to melting temperature profiles generated for other nucleic acid(s) to discern differences between the compared nucleic acids.

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Salt Lake City, UT, United States of America

C Wade Dummer