Array Biopharma Inc.

Intermune, Inc.

Ventirx Pharmaceuticals, Inc.

C Todd Eary

George A Doherty

Robert D Groneberg

Zachary Jones

Steven Wade Andrews

Yutong Jiang

Pierre Martin

Laurence Edward Burgess

Bin Wang

Timothy S Kercher

Scott D Seiwert

Lawrence M Blatt

Robert Hershberg

Weidong Liu

Paul Nichols

Michael Lyon

Gregory Dietsch

April L Kennedy

Andreas Schumacher

James Jeffry Howbert

Robert J Kaus

Tarek Sammakia

Bradley Barnett

Peter J Stengel

Stacey Spencer

Daniel John Watson

Derrick Juengst

Bruno P Hache

Bradley R Barnett

Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein. 

Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Substituted benzoazepines as toll-like receptor modulators

The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Macrocyclic inhibitors of hepatitis C virus replication

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

8-substituted benzoazepines as toll-like receptor modulators

Growing community of inventors

Longmont, CO, United States of America

C Todd Eary