Beckman Instruments, Inc.

Beckman Coulter, Inc.

C Marina Belei

Craig W Adams

Patty P Y Pang

The gene forDNase B has been cloned and vectors incorporating the cloned DNA have been used to transformallowing efficient and rapid production of the DNase inwithout the necessity of growing large quantities ofThe enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurringDNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by

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The gene forDNase B has been cloned and vectors incorporating the cloned DNA have been used to transform, allowing efficient and rapid production of the DNase inwithout the necessity of growing large quantities of. The enzyme can be produced with a leader peptide at its amino-terminus. An improved method for the purification of naturally occurringDNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by

The gene for DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform , allowing efficient and rapid production of the DNase in without the necessity of growing large quantities of . The enzyme can be produced with a leader peptide at its aminoterminus. An improved method for the purification of naturally occurring DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by

Recombinant DNase B derived from streptococcus pyogenes

The gene for DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform , allowing efficient and rapid production of the DNase in without the necessity of growing large quantities of . The enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurring DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by

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Anaheim, CA, United States of America

C Marina Belei