Akzo N.v.

C Hermas Swope

John G Link

Jones M Hyman

Julie F Hoffman

Joseph G Karp

Janet B Callahan

Douglas G Haugen

An apparatus in which scattered light is measured, said apparatus having a light source aligned to direct illumination toward an interface between a sample container and an aqueous solution at an angle less than the critical angle. A detector to measure the scattered light is located at a place outside the envelope of the critical angle.

Scattered light detection apparatus

An endpoint assay for measuring fibrinogen utilizing strong thrombin and weak plasma. In a preferred embodiment the assay is based on the direct conversion of a normalized signal from a sensor to fibrinogen concentration.

Direct fibrinogen assay

A multichannel optical monitoring system for monitoring the spectral transmission of a plurality of samples. A plurality of light beams are generated and a plurality of optical monitoring stations are arranged along a pathway, each station having an optical path formed by one of the light beams transverse to the pathway and along which optical characteristics are monitored. A drive mechanism moves a plurality of reaction wells, each containing a reaction volume, along the pathway from station to station so that respective reaction volumes dwell periodically in each optical path for transmitting a respective one of the light beams. A diffraction grating is arranged for diffracting the beams transmitted by respective ones of the reaction volumes. The diffracted beams are focussed and at least one array of photodetectors is positioned for receiving the diffracted and focussed beams for producing electrical signals representing the spectral content of the diffracted beams. An electronic circuit detects the electrical signals of the array, which signals may be stored for further processing and evaluation.

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Raleigh, NC, United States of America

C Hermas Swope