Ampio Pharmaceuticals, Inc.

Dmi Biosciences, Inc.

Dmi Acquisition Corp.

Other

C Gerald Curtis

David Bar-Or

Nagaraja K R Rao

Greg Thomas

James V Winkler

Edward Lau

Wannell M Crook

Nagaraja KR Rao

Nagaraja K Rao

The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein Rand Rare defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.

Method of using diketopiperazines and composition containing them

The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

Metal-binding compounds and uses therefor

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Cardiff, United Kingdom

C Gerald Curtis