Micronics, Inc.

Sony Corporation

Sony Group Corporation

Perkinelmer Health Sciences, Inc.

Sony Corporation of America

Revvity Health Sciences, Inc.

C Frederick Battrell

Isaac Sprague

John Clemmens

Tracy Matray

John R Williford

Denise Maxine Hoekstra

Bernhard Hans Weigl

Jason Capodanno

John Gerdes

Hesham Sherif

Michael VanBrunt

Christy A Lancaster

Jeffrey M Houkal

Matthew Scott Bragd

Andrew Kolb

Mingchao Shen

Carolina L Elmufdi

Joan Haab

Troy D Daiber

Patrick Saltsman

Sharat Singh

William Samuel Hunter

Wayne L Breidford

Justin L Kay

Diane Wierzbicki

Stephen Mordue

Mark Stamatios Kokoris

Ronald L Bardell

Melud Nabavi

Elizabeth Reeves Leber

Alan Keith Lofquist

Gerald L Klein

Zane Miller

Sean M Pennell

Heather K Bouzek

Peter Kotlarski

John C Kumer

Kenneth Farber

Alan K Lofquist

Sabrina N Gunderson

Sabrina N Gates

John E Emswiler

Andrew W Kolb

Richard John Louis Gardner

Chin Eng Yeap

Neal Arthur Welti

Elizabeth R Leber

Zane B Miller

A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.

Specimen collection and delivery apparatus

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, L, L, L, L, M and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

Programmable polymeric drugs

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, wherein R, R, R, L, L, L, L, L, L, M, M, A, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Water soluble fluorescent or colored dyes and methods for their use

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, L, L, M, M, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Water soluble fluorescent or colored dyes comprising conjugating groups

A microfluidic mixing device comprising two bellows pumps (), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale. More particularly, the microfluidic mixing device comprises: a first bellows pump (); a second bellows pump (); a first microchannel fluidly interconnecting the first bellows pump () with a sample inlet and a reagent reservoir, wherein the first microchannel comprises a valve (V) interposed between the pump and the inlet, and a valve (V) interposed between the pump and the reservoir; a second microchannel fluidly interconnecting the first bellows pump () with the second bellows pump (), wherein the second micro channel comprises a valve (V) interposed between the first and second pump; a third microchannel fluidly interconnecting the first bellows pump () with the second bellows pump, wherein the third micro channel comprises a valve (V) interposed between the first and second pump; a first and second pneumatic member pneumatically connected to the first and second bellows pumps; wherein, the volume of the second bellows pump () is greater than the volume of the first bellows pump ().

Microfluidic mixing device and method

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): 

Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.

Low elasticity films for microfluidic use

Compounds useful as fluorescent or colored dyes that enable visual detection of biomolecules and other analytes are disclosed. The compounds comprise a phenylethynylnapthalene moiety represented by the following structure (I):  including salts thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, x and y are as defined herein. Methods associated with preparation and use of such compounds for visually detecting a biomolecule are also provided.

Phenylethynylnaphthalene dyes and methods for their use

Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.

Microfluidic devices and methods for performing serum separation and blood cross-matching

A compact, microprocessor-controlled instrument for fluorometric assays in liquid samples has a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor controlled by an optical data acquisition and processing daemon within the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. The assay ma be validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Molecular biological assays use PCR amplification of target nucleic acids and fluorometric assays, which may require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are improved using a heating block with reflective mirror face in contact with a thermo-optical window enclosing the liquid sample.

Portable fluorescence detection system and microassay cartridge

Growing community of inventors

Redmond, WA, United States of America

C Frederick Battrell