Indiana University

Advanced Research & Technology Institute

University of California

Alios Biopharma, Inc.

Advanced Research and Technology

C Cheng Kao

Antonio Cembellin Prieto

Dean Rowe-Magnus

Jeffrey Brian Epp

Lani Rose San Mateo

Theodore S Widlanski

Leo Beigelman

Divyendu Singh

Robert W Siegel

William Vassiliou

Ch V Subba-Reddy

Xiaoyan Lin

Dave Smith

Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.

Bactericidal peptides and uses thereof

Peptide compositions having bacteriocidal peptides are described. Also described is a method of bacterial infections using compositions comprising bacteriocidal peptides or modified peptides with structural relationships to cathelicidins.

Bacteriocidal peptides and uses thereof

This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37's antibacterial activity.

Peptide antagonist of LL-37

Compositions and methods for the treatment of norovirus infection are disclosed.

Compositions and methods for the treatment of norovirus infection

The invention provides antiviral compounds and compositions comprising a viral specific oligonucleotide. Also provided are methods to inhibit or treat viral infections with the compounds or compositions of the invention.

Use of nucleic acid molecules as antiviral agents

The invention provides methods and compositions for polymerizing a particular nucleotide with a polymerase. In general, the method involves (a) forming a mixture of a polymerase and a nucleoside triphosphate (NTP) comprising &agr;, &bgr; and &ggr; phosphates and a &ggr;-phosphate phosphoester-linked functional group; and incubating the mixture under conditions wherein the polymerase catalyzes cleavage of the NTP between the &agr; and &bgr; phosphates, liberating a pyrophosphate comprising the functional group and polymerizing the resultant nucleoside monophosphate, i.e. incorporates the nucleoside monophosphate in a nascent polynucleotide. A variety of functional groups compatible with the polymerization reaction are provided.

&ggr;-phosphoester nucleoside triphosphates

Non-template 3' nucleotide addition to a transcript is reduced by transcribing a transcript from a template comprising an ultimate and/or penultimate 5' ribose having a C'2 substituent such as methoxy, which reduces non-template 3' nucleotide addition to the transcript. The methods are shown to be applicable to a wide variety of polymerases, including Taq, T7 RNA polymerase, etc.

Growing community of inventors

Bloomington, IN, United States of America

C Cheng Kao