Merck Sharp + Dohme Corp.

Merck + Co., Inc.

C Blair Zartman

Ian M Bell

Steven N Gallicchio

Craig A Stump

Cory R Theberge

Harold G Selnick

Donnette D Staas

Mark E Fraley

Michael R Wood

Daniel Vincent Paone

Cheng Wang

Helen J Mitchell

Anthony T Ginnetti

Xufang Zhang

Xu-Fang Zhang

Joseph P Vacca

Theresa M Williams

Heather E Stevenson

Samuel L Graham

Christopher J Dinsmore

Gerald E Stokker

Shawn J Stachel

Douglas C Beshore

Jeffrey M Bergman

Diem N Nguyen

Thomas G Steele

Melody McWherter

Anthony Ginetti

Melody Mcwherter

Daniel V Paone

Anthony Ginnetti

Thomas Steele

The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Piperidinone carboxamide azaindane CGRP receptor antagonists

The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Piperidinone carboxamide indane CGRP receptor antagonists

Compounds of formula I: wherein variables A, A, B, m, n, J, R, G, G, Gand Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Carboxamide heterocyclic CGRP receptor antagonists

The present invention is directed to compounds of the formula: (wherein variables A, A, A, G, G, G, G, J, E, E, E, R, R, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Monocyclic CGRP receptor antagonists

The present invention is directed to compounds of Formula I: I (where A, A, B, B, B, B, D, D, J, K, T, U, V, W, X, Y, Z, R, R, R, R, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved. 

Tricyclic anilide spirolactam CGRP receptor antagonists

Compounds of formula I: (wherein variables A, A, A, A, A, A, A, B, E, E, E, E, E, G, Gand Rare as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Bicyclic spirohydantoin CGRP receptor antagonists

Spirohydantoin aryl CGRP receptor antagonists

Compounds of formula I: (wherein variables A, A, A, A, A, A, A, B, E, E, E, E, E, G, G, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Spirolactam bicyclic CGRP receptor antagonists

The present invention is directed to compounds of Formula I: (where variables A, A, B, J, K, m, n, R, R, Rand Rare as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Bicyclic anilide spirolactam CGRP receptor antagonists

Compounds of formula I: (wherein variables A, A, A, A, A, A, A, B, B, B, B, D, D, E, E, E, E, E, G, G, R, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Spirohydantoin tricyclic CGRP receptor antagonists

Compounds of formula I: (wherein variables A, A, A, A, A, A, A, B, B, B, B, D, D, E, E, E, E, E, G, G, J, K, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Spirolactam tricyclic CGRP receptor antagonists

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Hatfield, PA, United States of America

C Blair Zartman