Plexxikon Inc.

Byunghun Lee

Prabha N Ibrahim

Chao Zhang

Dean R Artis

Rebecca Zuckerman

Jack Lin

Ryan Bremer

Shenghua Shi

Hanna Cho

Marika Nespi

Shumeye Mamo

Weiru Wang

Sam Gillette

Compounds are described that are active on at least one of PPAR&#x3b1;, PPAR&#x3b4;, and PPAR&#x3b3;, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR&#x3b1;, PPAR&#x3b4;, and PPAR&#x3b3;, wherein the compounds have the formula: wherein:

PPAR active compounds

Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.

PDE4B inhibitors

Compounds are described that are active on at least one of PPAR&#x3b1;, PPAR&#x3b4;, and PPAR&#x3b3;, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR&#x3b1;, PPAR&#x3b4;, and PPAR&#x3b3;.

Growing community of inventors

Marina, CA, United States of America

Byunghun Lee