Korea Institute of Science and Technology

Byung Hun Um

Cheol-Ho Pan

Joo Young Lee

Chu Won Nho

Saet Byoul Lee

Kyung Su Kang

Dae-Geun Song

Sang Moo Kim

Ji Hye Yoo

Na Ra Jeon

Suk Woo Kang

The present invention relates to a method for the prevention and treatment of postmenopausal syndrome containing the step of administering a pharmaceutically effective dose of theor its fractions to a subject. The present inventors confirmed that theextract or its fractions of the invention prepared by using water, alcohol or a mixed solvent thereof could promote the expression of the promoter containing estrogen responsive element (ERE) and accelerated the growth of MCF-7, the human breast tissue originated cell line, suggesting that they had estrogen activity. The inventors further confirmed that the extract or its fractions of the invention had the effect of promoting osteocyte differentiation, so that they could be effectively used for the prevention and treatment of postmenopausal syndrome such as hot flush, osteoporosis and phlebothrombosis caused by estrogen deficiency.

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The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in. More particularly, the present invention relates to a gene construct for the improvement of extracellular secretion efficiency of the said heterologous protein in, which comprises a polynucleotide encoding a recombinant protein composed of the heterologous protein linked to C-terminal of the signal sequence peptide represented by SEQ. ID. NO. 3. The present invention contributes to the improvement of extracellular secretion efficiency of a recombinant protein, so that it can be effectively applied to the production of a recombinant protein.

Growing community of inventors

Gangneung-si, South Korea

Byung Hun Um