Pharmacia & Upjohn Company

Other

Zoetis P&u LLC

Byung H Lee

Michael F Clothier

Valerie Ann Vaillancourt

Mark E Schnute

Stephen J Nelson

William W McWhorter, Jr

Fred L Ciske

Michael J Genin

Fred E Dutton

Pil H Lee

Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.

Anthelmintic and insecticidal compositions

Heterocycle carboxamides as antiviral agents

A phosgene-free method for preparing a carbamate from a compound containing an amine group involves reacting the compound with an alkylating agent in the presence of carbon dioxide and cesium carbonate. A reaction can take place under standard pressure and temperature conditions and produces carbamates in a high yield with low by-product formation.

Phosgene-free process for preparing carbamates

The present invention are marefortines and paraherquamides where the 7-member oxygenated ring has been modified to produce 25-methylene compounds (VII) and 24,25-epoxy compounds (VIII) all of which are useful as antiparasitic agents against endo and ecto parasites, particularly helminths and arthropods.

25-methylene and 24-25 -epoxy marcfortines and paraherquamides

This invention comprises novel compounds that inhibit the growth of helminths. The compounds have the structure of Formula I, below. ##STR1## Where the R groups are defined according to the specification and claims.

Cycloanthelmintic inhibitors

Marcfortine/paraherquamide derivatives useful as antiparasitic agents

14-substituted marcfortines and derivatives useful as antiparasitic

The present invention includes various substituted and paraherquamides, exemplified by the 14-hydroxy-2-deoxoparaherquamide B of formula (XXV) which are useful as antiparasitic agents.

Antiparasitic paraherquamides

The present invention includes various substituted marcfortines of the type exemplfied by the compounds of formula ##STR1## and paraherquamides which are useful as antiparasitic agents.

Antiparasitic marcfortines and paraherquamides

An aircraft safety alarm system for sounding an alarm that the aircraft engine may be started including outside mounted speaker alarm means and a switch activated by a user that couples a timer device to an alarm circuit for sounding an alarm outside the aircraft for a predetermined time period. The switch may be operated upon opening the aircraft door, operating the aircraft ignition switch or by fastening seat belts.

Growing community of inventors

Kalamazoo, MI, United States of America

Byung H Lee