Korea Institute of Science and Technology

Goldstar, Co., Ltd.

Hyundai Motor Company

Kia Motors Corporation

Korea Advanced Institute of Science and Technology

Seoul National University

Bio Imaging Korea Co., Ltd.

Korea University Research and Business Foundation

Snu Rdb Foundation

Korea Telecommunication Authority

Inha University Research and Business Foundation

Fnc Technology Co., Ltd.

Bik Therapeutics Inc.

Genecast Co., Ltd

Fnctech

Byung Chul Lee

Hyung Min Kim

Ki Joo Pahk

Inchan Youn

Dong-Hyun Kang

Sang Eun Kim

Byung Seok Moon

Jin Soo Park

Ji Sun Kim

Maesoon Im

Shinyong Shim

Sang Chul Lee

Jae Ho Jung

Jong Hyun Park

Hyun Chul Lee

Jun-Bo Yoon

Yang Kyu Choi

Hak Sung Kim

Tae Song Kim

Soo Hyun Lee

Nakwon Choi

Dong Sup Kim

Seok Jun Yoon

Yu Kyeong Kim

Dong Jun Kim

Jeyong Yun

Soo Hong Lee

Hyun Wook Ryu

Seung Pyo Hong

Jong Beom Seo

Joong Jae Lee

Young Bok Choi

Jeong Oen Lee

Rino Choi

Young Jun Yoon

Kam Chun Lee

Young Tak Lee

Mintack Oh

Joong Hyun Hwang

Il Hyun Park

Valentino Laquintana

Nunzio Denora

Kyung-Hee Cho

Hyejeong Seong

Whal Lee

Hae Youn Kim

Byeong Min Jo

Huy Ho Lee

Ying Qing Lu

Sang Hee Lee

Massimo Franco

Annalisa Cutrignelli

Angela Assunta Lopedota

Doo Yong Lee

Hyungbeen Lee

Won Hyuk Koh

Chong Chan Lee

Woo Young Jung

Yong Jae Song

Ji Eun Han

Keun Wan Park

Jae Kuk Nam

Han Ha Kim

Mee Kyung Kim

Kun Ik Jun

Jong Young Ha

Oh Duck Kwon

Jong Sup Kim

Young Kyu Lee

Seung Min Kwak

Woo Wyoung Jung

Jung Hee Ha

Young Sin Chun

Tong Kyu Park

Young Suk Bang

So Eun Shin

An ultrasonic diagnosis system according to an embodiment of the present disclosure includes a plurality of ultrasonic output patches configured to be attachable to different body parts, a data receiving unit configured to receive data transmitted from the plurality of ultrasonic output patches, a processing unit configured to acquire an imaging result related to the body part by processing the data, and an output unit configured to output the imaging result related to the body part, in which the ultrasonic output patch includes a multichannel ultrasonic transducer array configured to output imaging ultrasonic waves toward the body part and receive the reflected ultrasonic waves, a signal processing module configured to process a signal transmitted to or received from the multichannel ultrasonic transducer array, and a communication module configured to transmit a signal processing result, which is acquired by the signal processing module, to the data receiving unit.

Diagnosis system using attachable patch type ultrasonic transducer

A fluorine-18-labeled positron emission tomography (PET) radiotracer for diagnosing neuroinflammation, stroke or cerebral infarction and a method for using the radiotracer are provided.

Positron emission tomography radiotracer for diseases associated with translocator protein overexpression, translocator protein-targeting ligand for fluorescence imaging-guided surgery and photodynamic therapy, and production methods therefor

A method for preparing a fluorine-18-labeled fluoromethyl-substituted radiopharmaceutical using a selective azide substitution reaction includes (1) obtaining a [F]fluoride from a cyclotron through anO(p,n)F reaction; (2) separating the [F] fluoride using an acetonitrile reaction solution containing dissolved Kand KCOto obtain a [F]F/HO solution; (3) heating the [F]F/HO solution to obtain K/KF; (4) placing the K/KF along with a bis(tosyloxy)methane compound into a reactor and adding a reaction solvent to cause a reaction and obtain a first precursor solution; (5) cooling the first precursor solution and adding an azide reagent to cause an azide substitution reaction and obtain a [F]fluoromethyltosylate compound; (6) adding a bioactive molecule to the [F]fluoromethyltosylate compound to cause an alkylation reaction and obtain a second precursor solution; and (7) adding a precursor scavenger to the second precursor solution and scavenging unreacted precursors to produce a fluorine-18-labeled fluoromethyl-substituted radiopharmaceutical.

Method for preparing fluorine-18-labeled fluoromethyl-substituted radiopharmaceuticals using selective azide substitution reaction and precursor scavenging

Provided is a capacitive micromachined ultrasonic transducer (CMUT) including a substrate, a top electrode provided on the substrate to be spaced apart from the substrate, a supporter made of an insulating material and coupled between the substrate and an edge of the top electrode to support and fix the edge of the top electrode and to define a gap between the substrate and the edge of the top electrode, and a plurality of nanoposts having both ends coupled and fixed to the substrate and the top electrode in the gap, and being compressible and stretchable in a longitudinal direction to at least vertically move the top electrode when power is applied to the top electrode.

Capacitive micromachined ultrasonic transducer

An apparatus for tissue ablation according to an embodiment of the present disclosure includes an ultrasound output unit to output focused ultrasound, and a control unit to control an intensity of the focused ultrasound, wherein the control unit may be configured to control the intensity of the focused ultrasound below a setting value, when a first condition in which a vapor bubble is formed in a tissue or a second condition in which a temperature of the tissue reaches a threshold is accomplished during the output of the focused ultrasound to the tissue. According to this embodiment, it is possible to precisely control vapor bubble dynamics without generating the shockwave scattering effect by instantaneously controlling the acoustic pressure and the intensity of the focused ultrasound, and prevent damage to a tissue other than a lesion to be removed.

Apparatus and method for precise mechanical tissue ablation using pressure modulated focused ultrasound

A flexible ultrasound transducer according to an embodiment of the present disclosure includes a substrate having a central part and a plurality of extended parts extending from the central part; an ultrasound probe disposed at the central part of the substrate to acquire an ultrasound image of a region of interest; and a focused ultrasound output unit disposed at the extended parts of the substrate to output a focused ultrasound to the region of interest, wherein the focused ultrasound output unit disposed at the extended parts of the substrate has a flexible property and is deformable. According to the structure of an embodiment, it is possible to simultaneously achieve ultrasound imaging and ultrasonic therapy such as lesion stimulation or removal through focused ultrasound, and adjust the focal position of focused ultrasound or improve the focal sensitivity through flexible movement.

Flexible ultrasound transducer and method for manufacturing the same

The present disclosure relates to a method for determining a relative position between arrays of a flexible array device. The flexible array device according to an embodiment includes a plurality of arrays arranged at a predetermined interval in a deformable substrate, and the method includes measuring the first capacitance between adjacent arrays, measuring the second capacitance between the adjacent arrays after deformation of the substrate, and determining a relative position between the adjacent arrays based on the first capacitance measurement value and the second capacitance measurement value. According to an embodiment, the relative position between the arrays may be determined by measuring the capacitance between the adjacent arrays of the plurality of arrays arranged in the deformable substrate and measuring a change in capacitance caused by the deformation (contraction, relaxation, bending) of the substrate.

Method for determining relative position between arrays of flexible array device

A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

Capacitive micromachined ultrasonic transducer and method of fabricating the same

A DNA polymerase in which a mutation is induced at a specific amino acid position to increase gene mutation specificity, a nucleic acid sequence encoding the polymerase, a vector comprising the nucleic acid sequence, and a host cell transformed with the vector are disclosed. Provided are a method for in vitro detecting one or more gene mutations or SNPs in one or more templates by using a DNA polymerase having increased gene mutation specificity, a composition for detecting a gene mutation or SNP comprising the DNA polymerase, and a PCR kit comprising said composition. Furthermore, provided are a PCR buffer composition for increasing the activity of a DNA polymerase having increased gene mutation specificity and a PCR kit for detecting a gene mutation or SNP comprising the PCR buffer composition and/or the DNA polymerase having increased gene mutation specificity.

DNA polymerase with increased gene mutation specificity

Disclosed is a method for manufacturing a high-density neural probe including needles having various forms. The method, in which only a photolithography process and an etching process are used, simplifies a manufacturing process of the neural probe, minimizes changes in the characteristics of the neural probe depending on process equipment or conditions, and may thus ensure a high yield, thereby being advantageous in terms of commercialization. In addition, various forms of needles may be manufactured depending on the shape of patterns included in a mask, the height of the needles may be controlled by adjusting the size of the patterns and the gap between the patterns, and thereby, a neural probe having a plurality of needles having different heights may be manufactured.

Methods for manufacturing high-density neural probes having various forms

According to an embodiment of the present disclosure, there is provided a completely new type of 3-dimensional (3D) printing method for producing an object by focusing ultrasound onto material that changes in state by stimulation to solidify it into a desired shape. The method for 3D printing according to an embodiment includes providing material which changes in state by stimulation, setting a target focal point in the material, focusing ultrasound onto the target focal point using at least one ultrasound transducer, and applying stimulation to the material using the focused ultrasound to induce a change in state of the material. According to the embodiments, it is possible to control the precision of the output by controlling the frequency of the ultrasound transducer or the size of the target focal point on system.

Method for 3D printing and 3D printer using ultrasound

Disclosed herein is a non-invasive treatment system using intermedium, and an exemplary treatment system is configured to output high-intensity focused ultrasound to remove bone tissue, inject an acoustically-transparent medium into a part where the bone tissue is removed to generate an intermedium, and output therapeutic ultrasound that passes through the intermedium. Accordingly, the bone tissue is removed in a non-invasive way using high-intensity focused ultrasound, and the intermedium is generated at the bone tissue removed site, to increase the penetration of therapeutic ultrasound or generate ultrasound itself, thereby improving an ultrasound treatment effect while minimizing the side effect (for example, infection of dura mater) of invasive surgery methods.

Non-invasive treatment system using intermedium

A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

High-low intensity focused ultrasound treatment apparatus

The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.

Apparatus and method for extracting genome using ultrasound transducer and magnetic bead

A coolant control valve includes a cam rotating by rotational force; a pivot arm disposed under the cam, one end of the pivot arm moving in an up and down direction by rotation of the cam; a valve installed at another end of the pivot arm and disposed outside an outer diameter of the cam, the valve moving as the pivot arm moves; and a pivot arm support hinge for supporting the pivot arm and enabling vertical movement of the pivot arm when the cam rotates.

Coolant control valve

Growing community of inventors

Seoul, South Korea

Byung Chul Lee