Korea Institute of Science and Technology

Goldstar, Co., Ltd.

Hyundai Motor Company

Kia Motors Corporation

Korea Advanced Institute of Science and Technology

Bio Imaging Korea Co., Ltd.

Seoul National University

Snu Rdb Foundation

Korea Telecommunication Authority

Inha University Research and Business Foundation

Fnc Technology Co., Ltd.

Fnctech

Byung Chul Lee

Hyung Min Kim

Ki Joo Pahk

Inchan Youn

Dong-Hyun Kang

Byung Seok Moon

Jin Soo Park

Ji Sun Kim

Sang Eun Kim

Maesoon Im

Shinyong Shim

Sang Chul Lee

Jae Ho Jung

Jong Hyun Park

Hyun Chul Lee

Jun-Bo Yoon

Yang Kyu Choi

Hak Sung Kim

Tae Song Kim

Soo Hyun Lee

Nakwon Choi

Dong Sup Kim

Seok Jun Yoon

Yu Kyeong Kim

Dong Jun Kim

Seung Pyo Hong

Soo Hong Lee

Hyun Wook Ryu

Jeyong Yun

Rino Choi

Jong Beom Seo

Joong Jae Lee

Young Bok Choi

Jeong Oen Lee

Young Jun Yoon

Mintack Oh

Joong Hyun Hwang

Young Tak Lee

Hyejeong Seong

Whal Lee

Hae Youn Kim

Seung Min Kwak

Doo Yong Lee

Jong Young Ha

Young Kyu Lee

Jong Sup Kim

Kun Ik Jun

Yong Jae Song

Woo Young Jung

Chong Chan Lee

Won Hyuk Koh

Ji Eun Han

Keun Wan Park

Hyungbeen Lee

Jae Kuk Nam

Han Ha Kim

Mee Kyung Kim

Oh Duck Kwon

Tong Kyu Park

Jung Hee Ha

Woo Wyoung Jung

Young Sin Chun

Young Suk Bang

So Eun Shin

Provided is a capacitive micromachined ultrasonic transducer (CMUT) including a substrate, a top electrode provided on the substrate to be spaced apart from the substrate, a supporter made of an insulating material and coupled between the substrate and an edge of the top electrode to support and fix the edge of the top electrode and to define a gap between the substrate and the edge of the top electrode, and a plurality of nanoposts having both ends coupled and fixed to the substrate and the top electrode in the gap, and being compressible and stretchable in a longitudinal direction to at least vertically move the top electrode when power is applied to the top electrode.

Capacitive micromachined ultrasonic transducer

An apparatus for tissue ablation according to an embodiment of the present disclosure includes an ultrasound output unit to output focused ultrasound, and a control unit to control an intensity of the focused ultrasound, wherein the control unit may be configured to control the intensity of the focused ultrasound below a setting value, when a first condition in which a vapor bubble is formed in a tissue or a second condition in which a temperature of the tissue reaches a threshold is accomplished during the output of the focused ultrasound to the tissue. According to this embodiment, it is possible to precisely control vapor bubble dynamics without generating the shockwave scattering effect by instantaneously controlling the acoustic pressure and the intensity of the focused ultrasound, and prevent damage to a tissue other than a lesion to be removed.

Apparatus and method for precise mechanical tissue ablation using pressure modulated focused ultrasound

A flexible ultrasound transducer according to an embodiment of the present disclosure includes a substrate having a central part and a plurality of extended parts extending from the central part; an ultrasound probe disposed at the central part of the substrate to acquire an ultrasound image of a region of interest; and a focused ultrasound output unit disposed at the extended parts of the substrate to output a focused ultrasound to the region of interest, wherein the focused ultrasound output unit disposed at the extended parts of the substrate has a flexible property and is deformable. According to the structure of an embodiment, it is possible to simultaneously achieve ultrasound imaging and ultrasonic therapy such as lesion stimulation or removal through focused ultrasound, and adjust the focal position of focused ultrasound or improve the focal sensitivity through flexible movement.

Flexible ultrasound transducer and method for manufacturing the same

The present disclosure relates to a method for determining a relative position between arrays of a flexible array device. The flexible array device according to an embodiment includes a plurality of arrays arranged at a predetermined interval in a deformable substrate, and the method includes measuring the first capacitance between adjacent arrays, measuring the second capacitance between the adjacent arrays after deformation of the substrate, and determining a relative position between the adjacent arrays based on the first capacitance measurement value and the second capacitance measurement value. According to an embodiment, the relative position between the arrays may be determined by measuring the capacitance between the adjacent arrays of the plurality of arrays arranged in the deformable substrate and measuring a change in capacitance caused by the deformation (contraction, relaxation, bending) of the substrate.

Method for determining relative position between arrays of flexible array device

A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

Capacitive micromachined ultrasonic transducer and method of fabricating the same

Disclosed is a method for manufacturing a high-density neural probe including needles having various forms. The method, in which only a photolithography process and an etching process are used, simplifies a manufacturing process of the neural probe, minimizes changes in the characteristics of the neural probe depending on process equipment or conditions, and may thus ensure a high yield, thereby being advantageous in terms of commercialization. In addition, various forms of needles may be manufactured depending on the shape of patterns included in a mask, the height of the needles may be controlled by adjusting the size of the patterns and the gap between the patterns, and thereby, a neural probe having a plurality of needles having different heights may be manufactured.

Methods for manufacturing high-density neural probes having various forms

According to an embodiment of the present disclosure, there is provided a completely new type of 3-dimensional (3D) printing method for producing an object by focusing ultrasound onto material that changes in state by stimulation to solidify it into a desired shape. The method for 3D printing according to an embodiment includes providing material which changes in state by stimulation, setting a target focal point in the material, focusing ultrasound onto the target focal point using at least one ultrasound transducer, and applying stimulation to the material using the focused ultrasound to induce a change in state of the material. According to the embodiments, it is possible to control the precision of the output by controlling the frequency of the ultrasound transducer or the size of the target focal point on system.

Method for 3D printing and 3D printer using ultrasound

Disclosed herein is a non-invasive treatment system using intermedium, and an exemplary treatment system is configured to output high-intensity focused ultrasound to remove bone tissue, inject an acoustically-transparent medium into a part where the bone tissue is removed to generate an intermedium, and output therapeutic ultrasound that passes through the intermedium. Accordingly, the bone tissue is removed in a non-invasive way using high-intensity focused ultrasound, and the intermedium is generated at the bone tissue removed site, to increase the penetration of therapeutic ultrasound or generate ultrasound itself, thereby improving an ultrasound treatment effect while minimizing the side effect (for example, infection of dura mater) of invasive surgery methods.

Non-invasive treatment system using intermedium

A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

High-low intensity focused ultrasound treatment apparatus

The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.

Apparatus and method for extracting genome using ultrasound transducer and magnetic bead

A coolant control valve includes a cam rotating by rotational force; a pivot arm disposed under the cam, one end of the pivot arm moving in an up and down direction by rotation of the cam; a valve installed at another end of the pivot arm and disposed outside an outer diameter of the cam, the valve moving as the pivot arm moves; and a pivot arm support hinge for supporting the pivot arm and enabling vertical movement of the pivot arm when the cam rotates.

Coolant control valve

Disclosed herein is an aerosol generating and mixing system operating at a high temperature and a high pressure which includes an aerosol generating device; and an aerosol mixing device, wherein the aerosol generating device includes a pre-mixing tank and a mixing tank, and the mixing tank and the pre-mixing tank include a wing configured to rotate about a central shaft of the tank so as to agitate an inside aerosol, and an agitating motor configured to rotate the wing, and a filling nozzle of the mixing tank and the pre-mixing tank is configured to inject any of an aerosol aqueous solution and an aerosol particle.

Aerosol generating and mixing system operating at high temperature and pressure

An engine oil supply system may include an oil pan connected with an oil pump at a first side and connected with an oil cooler at a second side, an oil passage through which oil pressurized by the oil pump flows, an oil filter disposed in the oil pan to filter impurities in the oil supplied from the oil pump, and a bypass valve disposed in the oil passage to selectively supply the oil in the oil passage to at least one of the oil cooler and the oil filter.

Engine oil supply system

The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin &#x3b1;&#x3b2;(also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, and acts exclusively upon cancer cells having selectively activated integrin &#x3b1;&#x3b2;because of a substantially low intake into the liver and intestines.

Tricarbonyl technetium-99m, rhenium-185/187, or rhenium-188 labeled cyclic RGD derivatives and uses thereof

The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.

Water-soluble polypeptides comprised of repeat modules, method for preparing the same and method for a target-specific polypeptide and analysis of biological activity thereof

Growing community of inventors

Seoul, South Korea

Byung Chul Lee