Abbott Cardiovascular Systems, Inc.

Advanced Cardiovascular Systems, Inc.

Byron Lambert

Yunbing Wang

James Oberhauser

Fuh-Wei Tang

Xiao Ma

Brian Riggs

Derek Mortisen

Allen Coomber

Michael Volpone

A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.

Method to minimize molecular weight drop of poly(L-lactide) stent during processing

Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.

Methods of stabilizing molecular weight of polymer stents after sterilization

A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.

Stents including poly(L-lactide) formulations that minimize molecular weight drop during processing

The invention is generally directed to methods of radiation processing and methods for routine dosimetry, such as for the measurement of radiation dosages delivered to items to be processed by the application of radiation. Radiation-induced heat in an irradiated item is measured with a calorimeter and used to determine the dose of radiation received by the item. Resistive elements such as thermistors may be used in calorimeters to measure the change in temperature of an item receiving radiation, such as in electron beam radiation. Calorimeters exposed to irradiation in the same manner as irradiated items provide routine dosimetry for radiation processing.

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Temecula, CA, United States of America

Byron Lambert