Auburn University

The University of North Carolina at Chapel Hill

Georgia State University Research Foundation, Inc.

Pfizer Corporation

Duke University

Byron L Blagburn

Richard Ray Tidwell

David W Boykin

Christine C Dykstra

James E Hall

W David Wilson

Arvind Kumar

David A Brake

David S Lindsay

John R Perfect

Sarah M Zohdy

Lindsay Starkey

Described herein are Dirofilarial exhalant signatures and methods of detecting a Dirofilaria signature in a non-blood biological sample, such as exhalant, that can be used to detect Dirofilarial infection in a subject, such as a canine.

Dirofilaria volatile organic compound signatures and uses thereof

The present invention provides attenuated live cultures of the pathogenic protozoan parasite,, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.

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The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.

Attenuated live neospora vaccine

The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or ##STR2## wherein: each R.sub.2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.2 groups together represent C.sub.2 -C.sub.10 alkylene, or two R.sub.2 groups together represent ##STR3## wherein m is from 1-3 and R.sub.4 is H, ##STR4## or --CONHR.sub.5 NR.sub.6 R.sub.7, wherein

Methods of treating microbial infections

The present invention provides methods for treating Cryptosporidium parvum in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1##

Methods of treating cryptosporidium parvum

The present invention provides methods for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The methods comprise adminstering to the subject a compound of Formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl;

Growing community of inventors

Auburn, AL, United States of America

Byron L Blagburn