Gen-probe, Inc.

Other

Stratec Biomedical Ag

Stratec Se

Byron J Knight

David Opalsky

Norbert D Hagen

David A Buse

Bruce J Richardson

Anita Prasad

Tyler Moore

Haitao Li

Robert F Scalese

Christopher B Davis

Robert E Heinz

Gary D Lair

Thanh N Nguyen

Florence Li

Jerzy A Macioszek

David Howard Combs

Keith Moravick

Jason F Rhubottom

Julian Groeli

George T Walker

Olaf Hörger

Mark R Kennedy

Waldemar Lukhaub

Tom R Horn

Craig B Clark

John M Gilker

Matthew J Hayes

Harald Thahedl

Vincent Chabot

Stefan Habrich

Heiko Sayer

Robert Andrew Howard

Mark A Talmer

Gunars E Valkirs

James P Light, Ii

Arthur G Sandoval

James M Carrick

James T Tuggle

Howard J Kirchick

Matt McDermott

Brian Wayne Chambers

Brian Schroeter

Adam Sampson

Rommel M Hipolito

Bruce Richardson

Haito Li

Florence F Li

Christopher Brandon Davis

Stefan Harbrich

David Aaron Buse

Li Haito

Olaf Horger

Olaf Hoger

Olaf Hoerger

James P Light

Fluid vial

A cleaning member including a distal cleaning element and a proximal coupling element, where the coupling element has a proximal end portion dimensioned to form a frictional fit with a working end of an automated transport arm.

Non-absorbent cleaning member with transport arm working end coupling element for use in a sample testing system

An insert for a liquid-holding container may include a body comprising a wall, an open top end and a bottom end, and a generally tubular lumen extending from the open top end to the open bottom end. The insert may include a plurality of first openings formed in the wall, the first openings being situated between the top and bottom ends, wherein each of the plurality of first openings defines an area, and wherein the plurality of first openings have substantially the same dimensions. The insert may include one or more second openings formed in the wall, the one or more second openings being situated between the top and bottom ends, wherein each of the one or more second openings defines an area that is greater than the area defined by any of the first openings, wherein the one or more second openings have substantially the same dimensions.

Evaporation-limiting inserts for reagent containers and related methods of use

An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.

Apparatus for applying thermal energy to a receptacle and detecting an emission signal from the receptacle

A kit includes a vessel having a plasma-treated interior surface, solid composition adhered to the plasma-treated interior surface, and a reconstitution liquid. The solid composition has a mass ranging from about 600 micrograms to about 20 grams and is in the form of a lyophilized pellet adhered to the plasma-treated interior surface. The solid composition is macroscopic in three orthogonal dimensions, such that the solid composition is not a coating and has a length, a width, and a height of greater than 1 mm.

Compositions on plasma-treated surfaces

A container including a top wall and a fluid vessel depending from the top wall. The fluid vessel extends from a top wall aperture formed in the top wall to a bottom end of the fluid vessel. The container further includes gripping structures configured to enable an automated gripping mechanism to securely grip the container in a repeatable position and orientation with respect to the container-gripping components of the gripping mechanism.

Fluid container

Receptacle

The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.

An assembly for storing sample processing consumables that includes a cover and a tray. The cover includes a flexible panel and a cover wall that extends downward from the perimeter of the panel, where the panel and the cover wall define a cavity. The tray has a top surface that defines a plurality of wells and a side surface that extends downward from the perimeter of the top surface. The panel is situated adjacent the top surface of the tray, where a first portion of the tray is received within the cover cavity, such that a press fit is formed between the side surface of the tray and an inner surface of the cover wall, thereby releasably coupling the cover to the tray. At least a portion of the wells contain a sample processing consumable, and the cover is configured to be decoupled from the tray by applying a force to the panel to overcome the press fit.

Assemblies for storing sample processing

Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.

Method for applying thermal energy to a receptacle and detecting an emission signal from the receptacle

A container includes a base with a top wall, a vessel depending from a top wall aperture in the top wall, a fluid retainer projecting above the top wall and surrounding the top wall aperture, and a skirt surrounding the vessel and including opposed grooves for gripping the container. A lid is disposed on a top end of the base and includes a cover wall with a lid aperture generally aligned with the top wall aperture of the base. A septum is disposed between the top wall of the base and the cover wall with a portion of the septum disposed between the lid aperture and the top wall aperture. Fluid retainer/return structure is configured to prevent fluid deposited on the septum from dripping off the container and to allow at least a portion of the fluid deposited on the septum to run off the septum and into the vessel.

A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

Interlocking cap and vial

A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest includes a base and first and second covers and is configured to support one or more receptacles each supporting one or more substances within interior spaces of the lyophilization nest. The interior spaces may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through the first and second covers. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior spaces when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

Apparatus for maintaining a controlled environment

A nucleic acid diagnostic system includes a unit-dose reagent compartment storing at least one unit-dose pack, one or more unit-dose pack loading stations for holding a unit-dose pack at a location that permits a substance transfer device to dispense a reconstitution reagent into each well of the pack, a unit-dose pack distributor configured to transfer a unit-dose pack from the unit-dose reagent compartment to one of the unit-dose pack loading stations, and an electrostatic generator disposed within the housing of the unit-dose reagent compartment and/or adjacent the one or more unit-dose pack loading stations. The electrostatic generator imparts an electrostatic charge to each of the wells of the unit-dose pack and/or to a lyophilized reagent pellet within each well so that the electrostatic charge positions and holds each lyophilized reagent pellet at a bottom of each respective well of the unit-dose pack.

Diagnostic system and method

Growing community of inventors

San Diego, CA, United States of America

Byron J Knight