Dong-A Pharm. Co., Ltd.

Dong-A Pharmaceutical Co., Ltd

Dong-A Pharmtech Co., Ltd.

Byoung Ok Ahn

Moohi Yoo

Dong Sung Kim

Joong In Lim

Ik Yon Kim

Kyung Koo Kang

Sang Deuk Lee

Geun Jho Lim

Soon Hoe Kim

Mi Won Son

Won Bae Kim

Jae Sung Yang

Hee Chan Shin

Hyounmie Doh

Wonbae Kim

Seul Min Choi

Tae Young Oh

Nam Gi Baik

Dong Goo Kim

Byung Kwon Ryu

Hyunjoo Shim

Heungjae Kim

Soonhoe Kim

Taeyoung Oh

Miwon Son

Min Sun Chang

Tae Kyun Lim

Jae Young Yu

The present invention relates to an agent for preventing and treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with BPH and a relaxant for relaxing urethral smooth muscle or prostatic smooth muscle comprising a pyrazolopyrimidinone compound as an effective ingredient. The agent in accordance with the present invention can provide nitric oxides by inhibiting the activity of PDE-5 that decomposes c-GMP, and the provided nitric oxides relax the urethral smooth muscle or the prostatic smooth muscle to lower the intraurethral pressure (IUP), thus treating BPH and LUTS associated with BPH. Furthermore, the time required for reaching a maximum blood concentration is shorter and the half-life is longer than the other PDE-5 inhibitors, thus reducing the frequency of administration. Moreover, the agent of the invention causing few side effects can be efficiently used as a safe drug.

Agent for the prevention and treatment of prostatic hyperplasia comprising pyrazolopyrimidinone compound

The present invention relates to pyrazolopyrimidinone derivatives of formula 1, their preparation method and pharmaceutical compositions containing the said derivatives. The compounds have efficacy on the treatment of impotence, one of male sexual dysfunctions with the side effects reduced.

Pyrazolopyrimidinone derivatives for the treatment of impotence

Gastroprotective flavone/flavanone compounds with therapeutic effect on

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Kyunggi-do, South Korea

Byoung Ok Ahn