Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Science and Technology

Korea Research Institute of Chemical Technology

Chungbuk National University Industry-academic Cooperation Foundation

Byoung Mog Kwon

Dong Cho Han

Kwang Hee Son

Young Min Han

Dae Seop Shin

Hwan Mook Kim

Hwan Geun Choi

Young Kil Kim

Kyung Ho Yoo

Tae Bo Sim

Seong Hwan Kim

Chang Hyun Oh

Jung Beom Son

Sung Yun Cho

Young Jin Ham

Jae Du Ha

Jung Mi Hah

Yong Ki Min

Tae Sook Jeong

Hye Nan Kim

Jin Tae Hong

Seung Ho Lee

So Ha Lee

Myung Ae Bae

Hang W Lee

Sung U Kim

Song H Bok

Yong K Kwon

Dong Sik Park

Jeong Ju Seo

Yeong Rim Kang

Ki Wan Oh

Dong Choi Han

The present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases comprising colforsin daropate, and more particularly, the present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases such as bone fracture and osteoporosis, which inhibits osteoclast differentiation and bone resorption caused by osteoclasts and promotes osteoblast differentiation and the activity of osteoblasts, and a health functional food composition comprising colforsin daropate.

Method for the treatment of bone diseases comprising colforsin daropate

Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient

The present invention relates to a novel pharmaceutical composition of benproperine derivatives for preventing and treating angiogenesis-related diseases. The benproperine derivatives and pharmaceutically acceptable salts thereof according to the present invention inhibit cancer cell migration and the angiogenesis of vascular endothelial cells, and therefore can be effectively used not only as an anticancer agent, but also as an agent for preventing and treating diseases caused by abnormal angiogenesis, such as diabetic retinopathy and corneal transplant rejection.

Composition comprising benproperine derivatives as active ingredients for preventing and treating angiogenesis-related diseases

The present invention relates to obovatol compound isolated fromThunb. for the prevention and treatment of anxiety disorders involved with CNS. The obovatol compound isolated fromThunb. have potent anti-anxiety activity, verified by an increased percentage of time on the open arms, an increased number of entries into, time spent on, the distal portion of the open arms, and a decreased activity of locomotor. Therefore it can be used as the therapeutics or health care food for treating and preventing anxiety disorders.

Obovatol having anti-anxiety activity

Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it induces cell cycle arrest and cell death. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1. 

Cinnamaldehyde derivatives having improved solubility in water, a method for preparing the same and a pharmaceutical composition comprising the same

A novel ACAT inhibitor of formula (I) useful for the treatment of hyperlipidemia produced from Aspergillus fumigatus FM-F-37; derivatives of said ACAT inhibitor, which are separated from the culture of A. fumigatus FM-F-37 or prepared by a chemical process, also possess ACAT inhibition property. ##STR1##

Acyl CoA:cholesterol acyltransferase inhibitors

Growing community of inventors

Daejeon, South Korea

Byoung Mog Kwon