Gilead Pharmasset LLC

Gilead Sciences, Inc.

Pharmasset, Inc.

Roche Palo Alto LLC

F. Hoffmann-la Roche Ag

Byoung-Kwon Chun

Peiyuan Wang

Suguna Rachakonda

Bruce Ross

Michael Joseph Sofia

Ganapati Reddy Pamulapati

Hai-Ren Zhang

Richard L Mackman

Michael O Clarke

Dustin S Siegel

Rao V Kalla

Petr Jansa

Jinfa Du

Hon Chung Hui

Daniel H Byun

Devan Naduthambi

Kassibla E Dempah

Elaine Bunyan

Thao Perry

Dmitry Koltun

Neil H Squires

Keshab Sarma

Hai Yang

Wonsuk Chang

Gregory F Chin

Scott Preston Simonovich

Bindu Goyal

Jiang Zhu

Dhanapalan Nagarathnam

Junxing Shi

Edward Doerffler

Kyoichi A Watanabe

Jeremy Clark

Justin Philip Vitale

Tiago Vieira

Andrew C Stevens

Lieven Stuyver

Deeba Ensan

Wojciech Stec

Abdalla Hassan

Laurent Hollecker

Jagadeesh N Manda

Dhanpalan Nagarathnam

Steven D Axt

Quingwu Jin

Bruce S Ross

Kassibla Elodie Dempah

Qingwu Jin

Wojciech Kolonia Wola Zaradzynski Stec

Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

1'-cyano nucleoside analogs and uses thereof

Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Compounds and methods for treatment of viral infections

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

Antiviral compounds

Phospholipid compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical formulations of said compounds for the treatment of viral infections are disclosed.

Phospholipid compounds and methods of making and using the same

Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.

Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

The present disclosure provides a compound of Formula I:

1′-cyano nucleoside analogs and uses thereof

The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2&#x2032;-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.

Prodrugs of 4'-C-substituted-2-halo-2&#x2032;- deoxyadenosine nucleosides and methods of making and using the same

The present invention provides (i) processes for preparing a 2'-deoxy-2&#x2032;-fluoro-2&#x2032;-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2&#x2032;-deoxy-2&#x2032;-fluoro-2&#x2032;-C-methyl-&#xdf;-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.

Preparation of 2'-fluoro-2&#x2032;-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

Nucleoside phosphoramidates

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

Growing community of inventors

Robbinsville, NJ, United States of America

Byoung-Kwon Chun