Snu Rdb Foundation

Byoung Gon Moon

Jong Ik Hwang

Goo Jang

Byeong Chun Lee

Curie Ahn

Jung Taek Kang

Jae Seok Yang

Ok Jae Koo

Bum Rae Cho

Sol Park

Dae Kee Kwon

The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-&#x3b1; in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.

Transgenic pig expressing sTNFR1-Fc genes and the uses thereof

Growing community of inventors

Daejeon, South Korea

Byoung Gon Moon