Korea Advanced Institute of Science and Technology

Byong-Seok Choi

Janghyun Lee

Suk-Jo Kang

Mi Kyung Lee

Si-Eun Sung

Eun Byeol Park

Dongmin Chun

Ji Youn Min

The present invention provides an antiviral agent comprising an RNA oligonucleotide having a particular sequence and structure. Specifically, when a cell line is treated with an RNA oligonucleotide having specific sequence and helical bend structure according to the present invention, the expression of interferon-&#x3b2; or ISG56 is increased and anti-viral activating is exhibited. Thus, a composition comprising the RNA oligonucleotide can be used as an antiviral agent.

Antiviral agent comprising RNA oligonucleotide

The present disclosure provides a pharmaceutical composition for treating cancer comprising an RNA oligonucleotide having a particular sequence and structure. Specifically, when a cell line is treated with an RNA oligonucleotide having specific sequence and helical bend structure according to the present disclosure, the expression of ISG56 is increased and apoptosis of cancer cells is induced. Thus, a composition comprising the RNA oligonucleotide can be used as an anticancer agent.

Pharmaceutical composition for treatment of cancer comprising RNA oligonucleotide

The present disclosure provides an RNA oligonucleotide having a helical bend structure and a use thereof. Specifically, double strands formed by a complementary binding of two sequences have a helical bend structure in the RNA oligonucleotide. The RNA oligonucleotide can increase the expression of interferon-&#x3b2; or ISG56 and thus can be used as an immune system enhancer.

RNA oligonucleotide and immune system enhancer comprising same

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Daejeon, South Korea

Byong-Seok Choi