Therafuse, Inc.

Becton Dickinson and Company Limited

Other

Tearafuse, Inc.

Burton H Sage, Jr

Brian Catanzaro

Kenneth G Powell

David S Gillett

Larry A Monahan

Gina G Stetsko

A drug delivery device or patch-like delivery device which employs a spring force and an inclined surface to apply pressure on a fluid reservoir, thereby delivering medicament to a user's body. The slope of the inclined surface may be engineered to control the drug delivery rate. The device may be low profile and wearable, for example in the form of a patch. A visual indicator of the amount of medicament delivered or remaining may be incorporated, for example via a transparent window that shows the progression of an inclined surface as it presses on the reservoir. The device may incorporate mechanisms for automatic extension and retraction of a cannula at the beginning and end of drug delivery. Drug delivery rate may be limited with flow restrictors, and by using a two-reservoir system with a viscous liquid displacing a reservoir containing the medicament.

Spring-driven drug delivery device

A laminated sprinkler needle for introduction of liquids into an animal and extraction of fluids from an animal comprising a substrate, a micromachined photoresist layer, and a microporous layer is described. The structure is of simple construction and fabrication and provides much higher flow rates than standard hollow cannula.

Laminated sprinkler hypodermic needle

A device and method for accurate delivery of a liquid is described. The device comprises a flow channel through which the liquid flows. During manufacture or at some other point prior to the delivery of the liquid, the flow channel is characterized in terms of one or more properties of flow of a liquid through the channel. This characterization is stored in such a way that the flow channel characterization is available to the liquid delivery device at time of use. At time of use, the liquid delivery system reads the stored flow channel characterization and uses the stored flow channel characterization for safe and accurate delivery of the liquid.

Compensating liquid delivery system and method

Systems and methods for measuring the flow of a liquid along a conduit are disclosed. A heat source applies thermal energy to a portion of a liquid flowing along a conduit thereby elevating its temperature. A light source generates a first beam that passes through the liquid in the conduit downstream from the position of application of the thermal energy and an optical detector receives this beam in combination with a second beam that is not passed through the liquid in the conduit and measures a change in intensity of a combined beam. The time required for the heated portion of the liquid to move from the point of application of thermal energy to the point at which the beam passes through the liquid is measured. This measured time, along with the distance of separation of the heat source and the optical sensing means permits calculation of the velocity of the liquid in the conduit.

Liquid measuring system

A device, preferably a micro-device, is molded from a plastic material by injection molding, compression molding or embossing. A microabrader can be molded having microneedles for abrading the stratum corneum of the skin to form an abraded site in the tissue for enhancing drug delivery. The micro-device is molded using a mold assembly having a silicon molding surface. The silicon molding surface can include a recess corresponding to the desired shape and length of the microneedles. The silicon molding surface enables micron and submicron size features to be molded from polymeric materials without the polymeric material adhering to the mold surface. Micro-devices having molded features having micron and submicron dimensions can be rapidly produced without the use of a release agent.

Method and apparatus for manufacturing a device

Systems and methods for measuring the flow of a liquid along a conduit are disclosed. A heat source applies thermal energy to a portion of a liquid flowing along a conduit thereby elevating its temperature. An optical sensing means comprising a light source illuminating the liquid in the conduit downstream from the position of application of the thermal energy and an optical detector receiving a portion of this illumination senses the heated portion of liquid by measures a change in an optical property of the illumination caused by a change in the index of refraction of the heated portion of liquid. The time required for the heated portion of the liquid to move from the point of application of thermal energy to the point of optical sensing is measured. This measured time, along with the distance of separation of the heat source and the optical sensing means permits calculation of the velocity of the liquid in the conduit.

Liquid metering system

A compensating drug delivery system for delivery of medicaments to animals is described. A drug-containing reservoir is connected to a needle array through a flow tube. Medicament delivery to the animal through this flow tube is regulated by the combined action of a metering means and a valving means, and inaccuracies in delivery rate are compensated. The metering means and the valving means are microprocessor controlled to insure that the medication administered is according to a pre-established protocol.

Growing community of inventors

Vista, CA, United States of America

Burton H Sage, Jr