Survival Technology, Inc.

Burton E Sobel

Stanley J Sarnoff

The absorption rate of proteins with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

Protein absorption enhancing agents

A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered non-intravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.

The absorption rate of protein-thrombolytic agents with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

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Webster Groves, MO, United States of America

Burton E Sobel