Other

Phyto Tech Corp.

Ibio Limited

Envirogen, Inc.

Rutgers, the State University of New Jersey

Fraunhofer USA, Inc.

Protein Genomics, Inc.

Ibio, Inc. and Fraunhofer USA, Inc.

Inb:biotechnologies, Inc.

Matrix Design

Nucycle Therapy, Inc.

Burt D Ensley

Yoram Kapulnik

Michael J Blaylock

Vidadi Yusibov

Ilya Raskin

Cynthia Orser

Jianwei Huang

Mark Elless

David Salt

Vadim Mett

Robert Kellar

Shailaja Rabindran

Nanda P Kumar

Mary F DeFlaun

Slavik Dushenkov

John S Arnone

Matthew Ludmer

Moneim Shamloul

Michael J Shannon

Business methods, processes and systems for collection, storage and distribution of a biological sample material for producing a cosmetic formulation product.

Business methods, processes and systems for collection, cryogenic storage and distribution of cosmetic formulations from an obtained stem cell based biological material

The present invention relates to biocompatible polymeric scaffold materials, methods for making the materials and methods of using the materials. More particularly, the present invention relates to implants and grafts comprising polymeric scaffold materials of cross-linked human tropoelastin polypeptides and methods of making and using the same. In addition, the present invention provides alternatively spliced tropoelastin polynucleotides and polypeptides.

Tropoelastins and uses thereof

A method of producing metal-rich plants for the production of nutritional supplements. Edible plants are placed in a growth environment containing metal, and are cultivated in a fashion which enhances the uptake of metal into edible portions of the plants. The plants are then harvested, and may be eaten directly or processed into capsule or tablet form, in order to obtain the metallic nutrients so incorporated.

Nutritional supplements containing methylselenocysteine

The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein.

Production of foreign nucleic acids and polypeptides in sprout systems

The present invention provides systems and methods for producing pharmaceutically active proteins in transgenic sprouted seedlings. The transgenic sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter. The transgenic sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the pharmaceutically active protein.

Production of pharmaceutically active proteins in sprouted seedlings

A method of producing edibleplants capable of accumulating significant concentrations of selenium in edible portions of the plant. Edibleplants were grown in an environment containing selenium, the plants were cultivated under conditions that allow enhanced uptake of the metal into edible portions of the plants, wherein the concentration of selenium accumulated in the edible portions of the plant is higher than the concentration of selenium in the environment. The plants are then harvested for further use.

Methods for accumulating selenium in edible brassica

The present invention provides a system for reconstituting nucleic acid molecules that have been degraded but still contain useful genetic information. The present invention uses, as a template for reconstituting degraded nucleic acids in a biological sample, nucleic acids from a genetically related or identical organism having a sequence homologous to the degraded nucleic acids. After hybridization of the degraded nucleic acids to the template, regions of the degraded nucleic acids that are missing in the duplex containing template nucleic acid molecules hybridized to degraded nucleic acids are filled in with nucleotides using the intact nucleic acid molecule as a template. The newly formed strand of nucleic acid is used as the template for a subsequent step of hybridization to degraded nucleic acid molecules. Regions of degraded nucleic acids that are missing in the duplex are again filled in with nucleotides using the newly formed nucleic acid as the new template. The process is repeated until the newly formed nucleic acid molecules are substantially representative of the nucleic acids from the genome of the species from which the degraded sample is obtained.

Method of reconstituting nucleic acid molecules

The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomers will occur to form elastin. Contacting the tropoelastin and lysyl oxidase together and applying the mixture to a wound before substantial cross-linking has occurred promotes wound healing by holding the damaged tissue together, increasing the rate of healing, and decreasing the amount of scarring.

Wound healing compositions and methods using tropoelastin and lysyl oxidase

A hair treatment composition including a non naturally-occurring keratin protein in combination with a hair treatment formula is described. The protein is preferably of human origin and has not been previously cross-linked. The protein is most preferably selected from the group of soluble keratin proteins found in human hair. Preferably, the composition contains one, preferably at least two allelic variants of the protein, most preferably in substantially the same ratio at which they are found in hair of a selected individual. The individual may be selected, for example, on the basis of having appealing hair, of being the future user of the hair treatment composition of other reasons.

Recombinant hair treatment compositions

A cosmetic composition including a non naturally-occurring extracellular matrix protein in combination with a cosmetic carrier is described. The protein is preferably of human origin and has not been previously cross-linked. The protein is most preferably selected from the group consisting of soluble human procollagen and soluble human tropoelastin. Preferably, the composition contains at least two allelic variants of the protein, most preferably in substantially the same ratio at which they are found in epidermis of a selected individual. The individual may be selected, for example, on the basis of having youthful-appearing skin, of being the future wearer of the composition, or of other reasons.

Cosmetic compositions

The invention provides methods for producing edible plant tissue biomasses suitable for use as nutritional supplements. The seedlings are exposed to at least one metal and normal seedling growth is interrupted prior to the eleventh day following germination to thereby produce a metal-enriched plant seedling tissue biomass. The metal-containing edible plant tissue biomasses are also provided.

Nutritional supplements

The present invention provides methods by which hyperaccumulation of metals in plant shoots is induced by exposure to inducing agents. Hyperaccumulation occurs as part of a two-step process in which metals are first accumulated into plant roots; subsequent transport to plant shoots is induced by exposure to the agent. In preferred embodiments, manipulations that increase availability of metals to the plant are employed prior to application of the inducing agent. Effective inducing agents include conditions of low pH, chelators, herbicides, and high levels of heavy metals. Other phytotoxic agents are also useful. Application of multiple inducing agents results in synergistic effects.

Inducing hyperaccumulation of metals in plant shoots

Methods and systems for alleviating the environmental and health hazards associated with environmental contamination by metals are provided. Contained living or non-viable biomasses of metal-accumulating plant seedlings deplete the metal elements and compounds in metal-containing aqueous solutions. Concomitantly, the contained biomasses of plant seedlings accumulate the metal elements and compounds. The energy and nutrient stores of the seeds from which the seedlings develop are exploited to minimize the costs of remediating the metal-containing aqueous solutions.

Growing community of inventors

Newtown, PA, United States of America

Burt D Ensley