Asta Medica, Aktiengesellschaft

Zentaris Gmbh

Zentaris Ag

Aeterna Zentaris Gmbh

Zentaris Ivf Gmbh

Burkhard Wichert

Dieter Sauerbier

Thomas Reissmann

Jürgen Engel

J&uuml;rgen Engel

Jurgen Engel

Elisabeth Wolf-Heuss

Jurgen Rawert

Gudrun Sauerbier, Legal Representative

Thomas Reissman

Dieter Eauerbiar

Helmut Orth

A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.

Oligopeptide lyophilisate, their preparation and use

A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water, and freeze-dried.

Preparation and use of oligopeptide lyophilisate for gonad protection

A method of treating female infertility using a novel cetrorelix acetate lyophilizate is disclosed.

Method of treatment of female infertility

The invention relates to improved ifosfamide preparations which are distinguished in that as primary auxiliary a polysaccharide, in general a glycan, preferably dextran, starches or cellulose, in particular dextrans having an MW of 20,000 to 85,000, modified starches such as hydroxyethyl starch and chemically modified celluloses such as hydroxyethylcellulose and sodium carboxymethylcellulose, a glycol ether, preferably polyethylene glycol, in particular polyethylene glycols having a molecular weight of 600 to 6000 or an amino acid, preferably alanine, leucine or glutamic acid, is added to them. The improved ifosfamide preparation can also contain as an auxiliary a pharmaceutically customary buffer, for example acetate, citrate or tris buffer, preferably phosphate buffer. In addition, improved ifosfamide preparations are obtained by addition of NaHCO.sub.3. The ifosfamide preparations according to the invention can comprise one or a combination of several auxiliaries. Mesna can be added to the formulation as a uroprotector.

Ifosfamide lyophilizate preparations

Solutions of alkylphosphocholines in glycerol alkyl ethers having enhanced storage stability containing a buffer which maintains the pH value to a range between 4 and 6.

Stabilized hexadecylphosphocholine solutions in glycerol alkyl ethers

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Bielefeld, Germany

Burkhard Wichert