Hoechst Aktiengesellschaft

Burkhard Mencke

Walter Durckheimer

Jurgen Blumbach

Dieter Isert

Friedhelm Adam

Gerhard Seibert

Karl Seeger

Gerd Fischer

Eberhard Ehlers

Karl-Heinz Scheunemann

Norbert Klesel

Klaus Fleischmann

Crystalline cephem acid addition salts of the general formula II ##STR1## pharmaceutical preparations effective against bacterial infections which contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.

Crystalline cephem acid addition salts and process for their preparation

Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.

Cephalosporin derivatives

A crystalline water soluble disodium salt of 7-.beta.-[2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetamido]-3-(5-carboxy methyl-4-methyl-1,3-thiazol-2-ylthiomethyl)ceph-3-em-4-carboxylic acid (cefodizim), or an adduct or solvate thereof with water and/or an organic solvent.

Crystalline disodium salt of cefodizim

What are disclosed are cephem compounds of the formula ##STR1## useful for combating bacterial infections, and methods of making and using the same.

Cephem derivatives

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Holzappel, Germany

Burkhard Mencke