Basf Aktiengesellschaft

Basf Se Corporation

Evonik Degussa Gmbh

Paik Kwang Industrial Co., Ltd.

Abb Vie Deutschland Gmbh & Co. Kg

Basf Aktiencesellschaft

Burkhard Kröger

Oskar Zelder

Hartwig Schröder

Gregor Haberhauer

Markus Pompejus

Corinna Klopprogge

Stefan Haefner

Stefan Häfner

Hartwig Schroder

Wilfried Lubisch

Michael Kock

Hans-Georg Lemaire

Thomas Höger

Corinna Kolpprogge

Heung-Shick Lee

Bernd Otterbach

Corrinna Klopprogge

Joachim Rheinheimer

Liliane Unger

Ernst Baumann

Uwe Josef Vogelbacher

Wolfgang Wernet

Manfred Raschack

Thomas Subkowski

Heinz Hillen

Hartmut Riechers

Dagmar Klinge

Claus Bollschweiler

Martin Schmidt

Christoph Wittmann

Siegfried Bialojan

Harald Seulberger

Hartwig Schr&ouml;der

Rainer Otter

Thomas Meyer

Hyung-Joon Kim

Elmar Heinzle

Elard Jacob

Jun-Won Kim

Uwe Ruffer

Claudia Isabella Graef

Heung Shick-Lee

Byung-Joon Hwang

Patrick Kiefer

Hartwig SCHRÖDER

The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has

Poly(ADP-ribose) polymerase genes

The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

PEF-TS expression units

Pgro expression units

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins fromare described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis

Psod expression units

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine inby way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

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P EF-TU expression units

Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins fromare described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

Poly(ADP-ribose) polymerase-gene

The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.

Method for the production of sulpher-containing fine chemicals by fermentation

The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

Gene variants coding for proteins from the metabolic pathway of fine chemicals

Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of MP genes in this organism.

The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.

Methods for producing sulphurous fine chemicals by fermentation using metH-coding cornyeform bacteria

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Limburgerhof, Germany

Burkhard Kröger