Sankyo Company, Limited

Bunji Shimizu

Masakatsu Kaneko

Hiroaki Yanagisawa

Hideo Nakao

Shinichi Sugawara

Mitsuo Nagano

Akio Saito

Masao Arakawa

Tsuneo Baba

5-Fluorouracil compounds having a glycoside substituent connected to the 5-fluorouracil nucleus through a bridging oxygen atom; and having anti-tumor activity.

5-Fluorouracil derivatives and process for preparing thereof

A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formula

7-Methoxycephalosporin derivatives

A process for preparing 7.alpha.-methoxycephalosporin compounds which comprises reacting a salt of a 7.beta.-benzylideneamino-7.alpha.-methoxy-3-cephem-4-carboxylic acid with a hydrazine compound to give a salt of a 7.beta.-amino-7.alpha.-methoxy-3-cephem-4-carboxylic acid and reacting the latter compound with a carboxylic acid or its reactive derivative. The products are useful as antibacterial agents.

Process for preparing 7-methoxycephalosporin compounds

A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formula

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Hiromachi, Japan

Bunji Shimizu