Seoul National University

Chong Kun Dang Pharmaceutical Corporation

Mgenplus Co., Ltd.

Bumrae Cho

Su Jin Kim

Sang Hoon Lee

Jin Seok Lee

Eun Mi Lee

Byeong Chun Lee

Curie Ahn

Jung-Taek Kang

Dal Young Ji

Sun Mi Ahn

Su Cheong Yeom

Eun Jin Lee

Geon A Kim

Hye Jin Hong

A transgenic cloned piglet expressing human proinsulin and a method of preparing the same, and more particularly, to a recombinant vector for human proinsulin expression, a genetically modified cell line into which the recombinant vector is introduced, a transgenic cloned piglet expressing human proinsulin, and a method of producing the same.

Transgenic cloned piglet expressing human proinsulin and method of producing the same

The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for &#x3b1;-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.

Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-Fc gene, and comprises knocked-out GGTA1 gene, and use thereof

Growing community of inventors

Seoul, South Korea

Bumrae Cho