Pusan National University

The Industry & Academic Cooperation in Chungnam National University (Iac)

The Industry & Academic Cooperation in Chungnam National University

Prg S&tech Inc

Bum Joon Park

Gyu Yong Song

Jee Hyun Lee

Nam Chul Ha

Ah-Young Oh

Jee-Hyun Lee

Jin-Hyuk Her

Ji Hyun Lee

Su Jin Lee

Su-Jin Lee

Eun Ju Yun

Sun Hye Lee

Youn Sang Jung

Yu Seok O

Youn-Sang Jung

Ji-Hyun Lee

Gyu-Yong Song

A composition for preventing or treating an aging-related disease includes a novel decursin derivative as an active ingredient, wherein the novel decursin derivative has exhibited an excellent effect of inhibiting progerin expression and excellent effect of inhibiting binding between progerin and lamin A, and it has been confirmed that the novel decursin derivative prolongs the survival period of animal models in which progerin was induced.

Pharmaceutical composition for preventing or treating aging-related diseases containing decursin derivative as active ingredient

Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.

Compound for inhibiting binding between DX2 protein and p14/ARF protein, and pharmaceutical composition for treating or preventing cancer disease containing same as effective ingredient

Compound for inhibiting binding between DX2 protein and P14/ARF protein, and pharmaceutical composition for treating or preventing cancer disease containing same as effective ingredient

Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.

Method of screening of therapeutic agents for K-Ras mutant driven cancers

Disclosed are a method for treating an aging-related disease and a method for screening a therapeutic agent for an aging-related disease. The method for treating an aging-related disease includes administering to a subject a progerin expression inhibitor as an active ingredient. The method for screening a therapeutic agent for an aging-related disease includes selecting a candidate drug inhibitory of progerin expression.

Pharmaceutical composition for treating aging-associated diseases, containing progerin expression inhibitor as active ingredient, and screening method of said progerin expression inhibitor

Growing community of inventors

Busan, South Korea

Bum Joon Park