Emulate, Inc.

Buket Baddal

Geraldine A Hamilton

Catherine Karalis

Justin Nguyen

Carolina Lucchesi

Remi Villenave

Michael Salmon

The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as 'Severe Asthma-on-Chip.' In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.

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Brookline, MA, United States of America

Buket Baddal