University of Washington

Washington Research Foundation

Asemblon, Inc.

Other

The United States of America As Represented by the United States Energy

Esmaeel D. Naeemi

Buddy D. Ratner

Buddy D Ratner

Allan Sachs Hoffman

Esmaeel Naeemi

Jonathan Himmelfarb

Prabha D Nair

Karl F Bohringer

Stephen R Hanson

Elizabeth Reeves Leber

Nancy B Mateo

Le Zhen

Gabriel P Lopez

Felix Simonovsky

Andrew Marshall

Maximiliane Silvia Boeckl

Runbang Tang

Brian Otis

Shaoyi Jiang

Lawrence A Crum

Cagdas Varel

Andrew Jackson Boydston

Pierre D Mourad

Shrojalkumar Desai

Yael Hanein

Xuanhong Cheng

Chang-Uk Lee

Tueng T Shen

Thomas A Horbett

Ashutosh Shastry

Robert M Nerem

Huaiqiu Shi

Joseph A Chinn

Yanbing Wang

Andrew M Garfinkle

Yasmeen Haque

James E Francese

Andrew Garfinkle

Caren L Tidwell

Razieh Khalifehzadeh

Stephanie J Bryant

Kip D Hauch

Viola Vogel

Xiaojie Lin

Connie Sau-Kuen Kwok

Esmaeel D Naeemi

Synthetic polymeric vascular grafts that promote endothelial healing and methods of their preparation and use are provided.

Pro-healing elastic angiogenic microporous vascular graft

The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.

Molecularly imprinted polymers for removal of trimethylamine N-oxide

Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

Zwitterionic copolymer coatings and related methods

Halogenated cyclic diesters, halogenated polymers derived from the cyclic diesters, and methods for making the halogenated cyclic diesters and related halogenated polymers.

Halogenated cyclic diesters, related polymers, and methods for their preparation and use

The present technology relates generally to intraocular pressure ('IOP') monitoring systems and associated devices and methods. In some embodiments, an intraocular pressure monitoring system configured in accordance with the technology comprises an implantable intraocular assembly and an external unit configured to transmit power to and receive data from the intraocular assembly. The intraocular assembly can include an IOP sensing device embedded within a flexible, expandable annular member. The IOP sensing device can include an antenna, a pressure sensor, and a microelectronic device encapsulated by an elastomer.

Intraocular pressure sensing devices and associated systems and methods

The present invention relates to hydrogen production for the generation of energy. The invention describes methods, devices and assemblies involving hydrogen production including reacting hydrogen producing compounds, such as organothiol compounds, with a reactive metal substrate to produce hydrogen gas and utilizing the hydrogen gas to generate energy. The present invention further describes regenerating spent compound to a form suitable for hydrogen production by reacting the spent compound with hydrogen. Hydrogen storage and production, as described herein, is useful for producing hydrogen for energy production in hydrogen consuming devices, such as combustible engines and fuel cells, for example, as located on a hydrogen powered vehicle.

Method and device for hydrogen storage and delivery

The invention provides crosslinked porous biomaterials and methods for forming crosslinked porous biomaterials. The crosslinked porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.

Crosslinked porous biomaterials

Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use.

Biocompatible amino acid anhydride polymers

The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.

Porous biomaterials

In one aspect, the present invention provides devices for binding cells or molecules, wherein each device includes (a) a body defining a first surface and a second surface that is located opposite to the first surface; (b) a heater disposed upon the first surface; and (c) a temperature-responsive layer disposed upon the second surface. In another aspect, the present invention provides methods for binding molecules or living cells to a temperature-responsive material.

Apparatus and methods for binding molecules and cells

In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.

Hydrogels formed by non-covalent linkages

In one aspect, the invention provides methods for forming a photopatterned hydrogel. In some embodiments, the methods comprise the step of exposing a solution comprising a monomer, a crosslinking agent, and a photoinitiator to a pattern of light comprising a first and a second light intensity for a period of time and under suitable conditions for the first light intensity to induce essentially complete conversion of polymerizable groups on the monomer and the crosslinking agent to form a patterned hydrogel, and for the second light intensity to induce partial conversion of the polymerizable groups on the monomer and the crosslinking agent to form partially polymerized polymers that remain soluble. In some embodiments, the first light intensity is lower than the second light intensity. In another aspect, the invention provides methods for forming porous, photopatterned hydrogels.

Methods for photopatterning hydrogels

Method for hydrogen storage and delivery

Growing community of inventors

Seattle, WA, United States of America

Buddy D Ratner