Alcon, Inc.

Alcon Research, Ltd.

Astellas Pharma Gmbh

Bryon Severns

Hwang-Hsing Chen

Mark R Hellberg

Jesse Albert May

Najam A Sharif

Iok-Hou Pang

Alan John Henderson

Mark Hadden

Keith D Combrink

Abdelmoula Namil

Andrew Rusinko

Cheng Guo

Suchismita Mohapatra

Ganesh Prasanna

The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.

Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma

Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.

6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions

Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Pyranoindazoles and their use for the treatment of glaucoma

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Arlington, TX, United States of America

Bryon Severns